Effect of CYP3A perpetrators on ibrutinib exposure in healthy participants

Ibrutinib (PCI-32765), a potent covalent inhibitor of Bruton’s tyrosine kinase, has shown efficacy against a variety of B-cell malignancies. Given the prominent role of CYP3A in ibrutinib metabolism, effect of coadministration of CYP3A perpetrators with ibrutinib was evaluated in healthy adults. Ibr...

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Detalles Bibliográficos
Autores principales: de Jong, Jan, Skee, Donna, Murphy, Joe, Sukbuntherng, Juthamas, Hellemans, Peter, Smit, Johan, de Vries, Ronald, Jiao, Juhui James, Snoeys, Jan, Mannaert, Erik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2015
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4492731/
https://www.ncbi.nlm.nih.gov/pubmed/26171235
http://dx.doi.org/10.1002/prp2.156

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4492731/
https://www.ncbi.nlm.nih.gov/pubmed/26171235
http://dx.doi.org/10.1002/prp2.156

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