Pharmacodynamic assays to facilitate preclinical and clinical development of pre-mRNA splicing modulatory drug candidates

The spliceosome has recently emerged as a new target for cancer chemotherapy and novel antitumor spliceosome targeted agents are under development. Here, we describe two types of novel pharmacodynamic assays that facilitate drug discovery and development of this intriguing class of innovative therap...

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Detalles Bibliográficos
Autores principales: Shi, Yihui, Joyner, Amanda S, Shadrick, William, Palacios, Gustavo, Lagisetti, Chandraiah, Potter, Philip M, Sambucetti, Lidia C, Stamm, Stefan, Webb, Thomas R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2015
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4492733/
https://www.ncbi.nlm.nih.gov/pubmed/26171237
http://dx.doi.org/10.1002/prp2.158

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4492733/
https://www.ncbi.nlm.nih.gov/pubmed/26171237
http://dx.doi.org/10.1002/prp2.158

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