Predicting Binding Free Energy Change Caused by Point Mutations with Knowledge-Modified MM/PBSA Method

A new methodology termed Single Amino Acid Mutation based change in Binding free Energy (SAAMBE) was developed to predict the changes of the binding free energy caused by mutations. The method utilizes 3D structures of the corresponding protein-protein complexes and takes advantage of both approache...

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Detalles Bibliográficos
Autores principales: Petukh, Marharyta, Li, Minghui, Alexov, Emil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4492929/
https://www.ncbi.nlm.nih.gov/pubmed/26146996
http://dx.doi.org/10.1371/journal.pcbi.1004276

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4492929/
https://www.ncbi.nlm.nih.gov/pubmed/26146996
http://dx.doi.org/10.1371/journal.pcbi.1004276

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