Inhibition of Thrombopoietin/Mpl Signaling in Adult Hematopoiesis Identifies New Candidates for Hematopoietic Stem Cell Maintenance

Thrombopoietin (Thpo) signals via its receptor Mpl and regulates megakaryopoiesis, hematopoietic stem cell (HSC) maintenance and post-transplant expansion. Mpl expression is tightly controlled and deregulation of Thpo/Mpl-signaling is linked to hematological disorders. Here, we constructed an intrac...

Descripción completa

Detalles Bibliográficos
Autores principales: Kohlscheen, Saskia, Wintterle, Sabine, Schwarzer, Adrian, Kamp, Christel, Brugman, Martijn H., Breuer, Daniel C., Büsche, Guntram, Baum, Christopher, Modlich, Ute
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4493002/
https://www.ncbi.nlm.nih.gov/pubmed/26147434
http://dx.doi.org/10.1371/journal.pone.0131866

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4493002/
https://www.ncbi.nlm.nih.gov/pubmed/26147434
http://dx.doi.org/10.1371/journal.pone.0131866

Ejemplares similares