Cargando…

Inhibition of Thrombopoietin/Mpl Signaling in Adult Hematopoiesis Identifies New Candidates for Hematopoietic Stem Cell Maintenance

Thrombopoietin (Thpo) signals via its receptor Mpl and regulates megakaryopoiesis, hematopoietic stem cell (HSC) maintenance and post-transplant expansion. Mpl expression is tightly controlled and deregulation of Thpo/Mpl-signaling is linked to hematological disorders. Here, we constructed an intrac...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kohlscheen, Saskia, Wintterle, Sabine, Schwarzer, Adrian, Kamp, Christel, Brugman, Martijn H., Breuer, Daniel C., Büsche, Guntram, Baum, Christopher, Modlich, Ute
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4493002/ https://www.ncbi.nlm.nih.gov/pubmed/26147434 http://dx.doi.org/10.1371/journal.pone.0131866

Ejemplares similares

The thrombopoietin receptor, c-Mpl, is a selective surface marker for human hematopoietic stem cells
por: Ninos, John M, et al.
Publicado: (2006)

Deciphering the Differential Impact of Thrombopoietin/MPL Signaling on Hematopoietic Stem Cell Function in Bone Marrow and Spleen
por: Lee, Sandy, et al.
Publicado: (2023)

Serum Thrombopoietin and cMpl Expression in Thrombocytopenia of Different Etiologies
por: Vianello, Fabrizio, et al.
Publicado: (2014)

The Thrombopoietin Receptor, MPL, Is a Therapeutic Target of Opportunity in the MPN
por: Spivak, Jerry L., et al.
Publicado: (2021)

Expression pattern of the thrombopoietin receptor (Mpl) in the murine central nervous system
por: Ivanova, Anna, et al.
Publicado: (2010)

Genetic Alterations of the Thrombopoietin/MPL/JAK2 Axis Impacting Megakaryopoiesis
por: Plo, Isabelle, et al.
Publicado: (2017)

Endocytosis of the thrombopoietin receptor Mpl regulates megakaryocyte and erythroid maturation in mice
por: Eaton, Nathan, et al.
Publicado: (2022)

Icaritin Provokes Serum Thrombopoietin and Downregulates Thrombopoietin/MPL of the Bone Marrow in a Mouse Model of Immune Thrombocytopenia
por: Zhang, Ke, et al.
Publicado: (2018)

Thrombopoietin and its receptor in normal and neoplastic hematopoiesis
por: Kaushansky, Kenneth
Publicado: (2016)

Live-Cell Visualization of Intracellular Interaction between a Nuclear Migration Protein (hNUDC) and the Thrombopoietin Receptor (Mpl)
por: Zheng, Yuan-Bin, et al.
Publicado: (2012)

The thrombopoietin/MPL axis is activated in the Gata1(low) mouse model of myelofibrosis and is associated with a defective RPS14 signature
por: Zingariello, M, et al.
Publicado: (2017)

Tyrosyl-tRNA synthetase stimulates thrombopoietin-independent hematopoiesis accelerating recovery from thrombocytopenia
por: Kanaji, Taisuke, et al.
Publicado: (2018)

DLGAP1 directs megakaryocytic growth and differentiation in an MPL dependent manner in hematopoietic cells
por: Kwiatkowski, Boguslaw A., et al.
Publicado: (2019)

Hematopoietic stem cells temporally transition to thrombopoietin dependence in the fetal liver
por: Lee, Yeojin, et al.
Publicado: (2022)

Recombinant Human Thrombopoietin Treatment Promotes Hematopoiesis Recovery in Patients with Severe Aplastic Anemia Receiving Immunosuppressive Therapy
por: Wang, Huaquan, et al.
Publicado: (2015)

Tuning MPL signaling to influence hematopoietic stem cell differentiation and inhibit essential thrombocythemia progenitors
por: Cui, Lu, et al.
Publicado: (2021)

Thrombopoietin from hepatocytes promotes hematopoietic stem cell regeneration after myeloablation
por: Gao, Longfei, et al.
Publicado: (2021)

Thrombopoietin maintains cell numbers of hematopoietic stem and progenitor cells with megakaryopoietic potential
por: O’Neill, Aled, et al.
Publicado: (2020)

c-Mpl-del, a c-Mpl alternative splicing isoform, promotes AMKL progression and chemoresistance
por: Li, Fei, et al.
Publicado: (2022)

The PlagL2 transcription factor activates Mpl transcription and signaling in hematopoietic progenitor and leukemia cells
por: Landrette, Sean F, et al.
Publicado: (2011)

Recombinant human thrombopoietin promotes hematopoietic reconstruction after severe whole body irradiation
por: Wang, Chao, et al.
Publicado: (2015)

Rap1 signal modulators control the maintenance of hematopoietic progenitors in bone marrow and adult long‐term hematopoiesis
por: Imai, Takahiko, et al.
Publicado: (2019)

Thrombopoietin protects hematopoietic stem cells from retrotransposon-mediated damage by promoting an antiviral response
por: Barbieri, Daniela, et al.
Publicado: (2018)

Thrombopoietin enhances hematopoietic stem and progenitor cell homing by impeding matrix metalloproteinase 9 expression
por: Liu, Yiming, et al.
Publicado: (2020)

Overproduction of thrombopoietin by BRAFV600E‐mutated mouse hepatocytes and contribution of thrombopoietin to hepatocarcinogenesis
por: Tanaka, Hiroki, et al.
Publicado: (2019)

TPO/Mpl Studies in Agnogenic Myeloid Metaplasia
por: Hemavathy, Kirugaval C, et al.
Publicado: (2005)

The Main (Glyco) Phospholipid (MPL) of Thermoplasma acidophilum
por: Freisleben, Hans-Joachim
Publicado: (2019)

Clonal Hematopoiesis, Cardiovascular Diseases and Hematopoietic Stem Cells
por: Kandarakov, Oleg, et al.
Publicado: (2020)

Thrombopoietin: tickling the HSC's fancy
por: Kim, Ah Ram, et al.
Publicado: (2017)

CAMT-MPL: congenital amegakaryocytic thrombocytopenia caused by MPL mutations - heterogeneity of a monogenic disorder - a comprehensive analysis of 56 patients
por: Germeshausen, Manuela, et al.
Publicado: (2020)

Dissection of Signaling Events Downstream of the c-Mpl Receptor in Murine Hematopoietic Stem Cells Via Motif-Engineered Chimeric Receptors
por: Saka, Koichiro, et al.
Publicado: (2017)

Thrombopoietin: a novel candidate tumor marker for the diagnosis of ovarian cancer
por: Mermer, Timucin, et al.
Publicado: (2012)

Nonfamilial, MPL S505N-Mutated Essential Thrombocythaemia
por: Morrell, Ruth, et al.
Publicado: (2013)

MPL-mutated essential thrombocythemia: a morphologic reappraisal
por: Szuber, Natasha, et al.
Publicado: (2018)

Mitigation of total body irradiation-induced mortality and hematopoietic injury of mice by a thrombopoietin mimetic (JNJ-26366821)
por: Kumar, Vidya P., et al.
Publicado: (2022)

Definitive hematopoietic stem cells minimally contribute to embryonic hematopoiesis
por: Ulloa, Bianca A., et al.
Publicado: (2021)

Progressive disruption of hematopoietic architecture from clonal hematopoiesis to MDS
por: Buck, Michèle C., et al.
Publicado: (2023)

ADAR1 is essential for maintenance of hematopoiesis and suppression of interferon signaling
por: Hartner, Jochen C., et al.
Publicado: (2008)

In and out: Traffic and dynamics of thrombopoietin receptor
por: Roy, Anita, et al.
Publicado: (2021)

Dynamic clonal hematopoiesis and functional T-cell immunity in a supercentenarian
por: van den Akker, Erik B., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_1vllfk9q8qbjm22petnnlvr9tm