Structural Insights Reveal the Dynamics of the Repeating r(CAG) Transcript Found in Huntington’s Disease (HD) and Spinocerebellar Ataxias (SCAs)

In humans, neurodegenerative disorders such as Huntington’s disease (HD) and many spinocerebellar ataxias (SCAs) have been found to be associated with CAG trinucleotide repeat expansion. An important RNA-mediated mechanism that causes these diseases involves the binding of the splicing regulator pro...

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Detalles Bibliográficos
Autores principales: Tawani, Arpita, Kumar, Amit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4493008/
https://www.ncbi.nlm.nih.gov/pubmed/26148061
http://dx.doi.org/10.1371/journal.pone.0131788

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4493008/
https://www.ncbi.nlm.nih.gov/pubmed/26148061
http://dx.doi.org/10.1371/journal.pone.0131788

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