HECT E3 Ubiquitin Ligase Itch Functions as a Novel Negative Regulator of Gli-Similar 3 (Glis3) Transcriptional Activity

The transcription factor Gli-similar 3 (Glis3) plays a critical role in the generation of pancreatic ß cells and the regulation insulin gene transcription and has been implicated in the development of several pathologies, including type 1 and 2 diabetes and polycystic kidney disease. However, little...

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Detalles Bibliográficos
Autores principales: ZeRuth, Gary T., Williams, Jason G., Cole, Yasemin C., Jetten, Anton M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4493090/
https://www.ncbi.nlm.nih.gov/pubmed/26147758
http://dx.doi.org/10.1371/journal.pone.0131303

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4493090/
https://www.ncbi.nlm.nih.gov/pubmed/26147758
http://dx.doi.org/10.1371/journal.pone.0131303

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