Combined heterozygous loss of Ebf1 and Pax5 allows for T-lineage conversion of B cell progenitors

To investigate how transcription factor levels impact B-lymphocyte development, we generated mice carrying transheterozygous mutations in the Pax5 and Ebf1 genes. Whereas combined reduction of Pax5 and Ebf1 had minimal impact on the development of the earliest CD19(+) progenitors, these cells displa...

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Detalles Bibliográficos
Autores principales: Ungerbäck, Jonas, Åhsberg, Josefine, Strid, Tobias, Somasundaram, Rajesh, Sigvardsson, Mikael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4493409/
https://www.ncbi.nlm.nih.gov/pubmed/26056231
http://dx.doi.org/10.1084/jem.20132100

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4493409/
https://www.ncbi.nlm.nih.gov/pubmed/26056231
http://dx.doi.org/10.1084/jem.20132100

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