Autoimmunity-associated protein tyrosine phosphatase PEP negatively regulates IFN-α receptor signaling

The protein tyrosine phosphatase PTPN22(C1858T) allelic polymorphism is associated with increased susceptibility for development of systemic lupus erythematosus (SLE) and other autoimmune diseases. PTPN22 (also known as LYP) and its mouse orthologue PEP play important roles in antigen and Toll-like...

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Detalles Bibliográficos
Autores principales: Holmes, Derek A., Suto, Eric, Lee, Wyne P., Ou, Qinglin, Gong, Qian, Smith, Hamish R.C., Caplazi, Patrick, Chan, Andrew C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4493413/
https://www.ncbi.nlm.nih.gov/pubmed/26077719
http://dx.doi.org/10.1084/jem.20142130

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4493413/
https://www.ncbi.nlm.nih.gov/pubmed/26077719
http://dx.doi.org/10.1084/jem.20142130

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