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Genetic absence of PD-1 promotes accumulation of terminally differentiated exhausted CD8(+) T cells
Programmed Death-1 (PD-1) has received considerable attention as a key regulator of CD8(+) T cell exhaustion during chronic infection and cancer because blockade of this pathway partially reverses T cell dysfunction. Although the PD-1 pathway is critical in regulating established “exhausted” CD8(+)...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4493417/ https://www.ncbi.nlm.nih.gov/pubmed/26034050 http://dx.doi.org/10.1084/jem.20142237 |