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Genetic absence of PD-1 promotes accumulation of terminally differentiated exhausted CD8(+) T cells

Programmed Death-1 (PD-1) has received considerable attention as a key regulator of CD8(+) T cell exhaustion during chronic infection and cancer because blockade of this pathway partially reverses T cell dysfunction. Although the PD-1 pathway is critical in regulating established “exhausted” CD8(+)...

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Detalles Bibliográficos
Autores principales:	Odorizzi, Pamela M., Pauken, Kristen E., Paley, Michael A., Sharpe, Arlene, Wherry, E. John
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4493417/ https://www.ncbi.nlm.nih.gov/pubmed/26034050 http://dx.doi.org/10.1084/jem.20142237

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