Cargando…

Human Keratoconus Cell Contractility is Mediated by Transforming Growth Factor-Beta Isoforms

Keratoconus (KC) is a progressive disease linked to defects in the structural components of the corneal stroma. The extracellular matrix (ECM) is secreted and assembled by corneal keratocytes and regulated by transforming growth factor-β (TGF-β). We have previously identified alterations in the TGF-...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lyon, Desiree’, McKay, Tina B., Sarkar-Nag, Akhee, Priyadarsini, Shrestha, Karamichos, Dimitrios
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4493522/ https://www.ncbi.nlm.nih.gov/pubmed/26096146 http://dx.doi.org/10.3390/jfb6020422

Ejemplares similares

Keratoconus in vitro and the key players of the TGF-β pathway
por: Priyadarsini, Shrestha, et al.
Publicado: (2015)

Mechanisms of Collagen Crosslinking in Diabetes and Keratoconus
por: McKay, Tina B., et al.
Publicado: (2019)

Gross Cystic Disease Fluid Protein-15/Prolactin-Inducible Protein as a Biomarker for Keratoconus Disease
por: Priyadarsini, Shrestha, et al.
Publicado: (2014)

Arginine Supplementation Promotes Extracellular Matrix and Metabolic Changes in Keratoconus
por: McKay, Tina B., et al.
Publicado: (2021)

Acute hypoxia influences collagen and matrix metalloproteinase expression by human keratoconus cells in vitro
por: McKay, Tina B., et al.
Publicado: (2017)

Association between Diabetes and Keratoconus: A Retrospective Analysis
por: Whelchel, Amy E., et al.
Publicado: (2019)

Quercetin Attenuates Lactate Production and Extracellular Matrix Secretion in Keratoconus
por: McKay, T. B., et al.
Publicado: (2015)

Sex Hormones, Growth Hormone, and the Cornea
por: McKay, Tina B., et al.
Publicado: (2022)

Establishment of a 3D In Vitro Model to Accelerate the Development of Human Therapies against Corneal Diabetes
por: Priyadarsini, Shrestha, et al.
Publicado: (2016)

Differential Effects of Hormones on Cellular Metabolism in Keratoconus In Vitro
por: McKay, Tina B., et al.
Publicado: (2017)

Characterization of Tear Immunoglobulins in a Small-Cohort of Keratoconus Patients
por: McKay, Tina B., et al.
Publicado: (2020)

Transcriptional profiling of corneal stromal cells derived from patients with keratoconus
por: Sharif, Rabab, et al.
Publicado: (2019)

Endocrine and Metabolic Pathways Linked to Keratoconus: Implications for the Role of Hormones in the Stromal Microenvironment
por: McKay, Tina B, et al.
Publicado: (2016)

Prospective Observational Study Evaluating Systemic Hormones and Corneal Crosslinking Effects in Keratoconus
por: Van, Lyly, et al.
Publicado: (2023)

Keratoconus: Tissue Engineering and Biomaterials
por: Karamichos, Dimitrios, et al.
Publicado: (2014)

Quercetin Decreases Corneal Haze In Vivo and Influences Gene Expression of TGF-Beta Mediators In Vitro
por: McKay, Tina B., et al.
Publicado: (2022)

Collagen cross-linking impact on keratoconus extracellular matrix
por: Sharif, Rabab, et al.
Publicado: (2018)

Keratoconus: Challenges and Emerging Trends
por: Karamichos, D
Publicado: (2018)

Collagen Crosslinking for Keratoconus: Cellular Signaling Mechanisms
por: Karamichos, Dimitrios, et al.
Publicado: (2023)

Transforming growth factor beta isoforms in breast cancer.
por: Benson, J. R., et al.
Publicado: (1994)

Gonadotropins in Keratoconus: The Unexpected Suspects
por: Karamichos, Dimitrios, et al.
Publicado: (2019)

The Underlying Relationship between Keratoconus and Down Syndrome
por: Akoto, Theresa, et al.
Publicado: (2022)

Novel in Vitro Model for Keratoconus Disease
por: Karamichos, Dimitrios, et al.
Publicado: (2012)

Human in vitro Model Reveals the Effects of Collagen Cross-linking on Keratoconus Pathogenesis
por: Sharif, Rabab, et al.
Publicado: (2017)

Unravelling the interplay of sphingolipids and TGF-β signaling in the human corneal stroma
por: Nicholas, Sarah E., et al.
Publicado: (2017)

Quercetin and Related Analogs as Therapeutics to Promote Tissue Repair
por: McKay, Tina B., et al.
Publicado: (2023)

Immunohistochemical localization of transforming growth factor beta isoforms in asbestos-related diseases.
por: Jagirdar, J, et al.
Publicado: (1997)

Signalling by Transforming Growth Factor Beta Isoforms in Wound Healing and Tissue Regeneration
por: Gilbert, Richard W.D., et al.
Publicado: (2016)

Cellular Contractility Profiles of Human Diabetic Corneal Stromal Cells
por: Lam, Thi N., et al.
Publicado: (2021)

Expression of transforming growth factor beta mRNA isoforms in human breast cancer.
por: MacCallum, J., et al.
Publicado: (1994)

Differential Expression and Clinical Significance of Transforming Growth Factor-Beta Isoforms in GBM Tumors
por: Roy, Laurent-Olivier, et al.
Publicado: (2018)

Unravelling the Impact of Cyclic Mechanical Stretch in Keratoconus—A Transcriptomic Profiling Study
por: Akoto, Theresa, et al.
Publicado: (2023)

Corneal Epithelial–Stromal Fibroblast Constructs to Study Cell–Cell Communication in Vitro
por: McKay, Tina B., et al.
Publicado: (2019)

Changes in expression of transforming growth factor beta mRNA isoforms in patients undergoing tamoxifen therapy.
por: Benson, J. R., et al.
Publicado: (1997)

Changes in expression of transforming growth factor beta mRNA isoforms in patients undergoing tamoxifen therapy.
por: MacCallum, J., et al.
Publicado: (1996)

Quantitative relationships between transforming growth factor beta mRNA isoforms in congenital and traumatic cataracts
por: Banasiak, Pawel, et al.
Publicado: (2011)

Expression of Transforming Growth Factor Beta Isoforms in Canine Endometrium with Cystic Endometrial Hyperplasia–Pyometra Complex
por: Rybska, Marta, et al.
Publicado: (2021)

In vitro model suggests oxidative stress involved in keratoconus disease
por: Karamichos, D., et al.
Publicado: (2014)

Molecular Mechanical Differences between Isoforms of Contractile Actin in the Presence of Isoforms of Smooth Muscle Tropomyosin
por: Hilbert, Lennart, et al.
Publicado: (2013)

Tumour-stromal interactions: Transforming growth factor-beta isoforms and hepatocyte growth factor/scatter factor in mammary gland ductal morphogenesis
por: Pollard, Jeffrey W
Publicado: (2001)

Cannot write session to /tmp/vufind_sessions/sess_r53otf3qdoq9d41ai235jda78q