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Primary microRNA processing is functionally coupled to RNAP II transcription in vitro

Previous studies in vivo reported that processing of primary microRNA (pri-miRNA) is coupled to transcription by RNA polymerase II (RNAP II) and can occur co-transcriptionally. Here we have established a robust in vivo system in which pri-miRNA is transcribed by RNAP II and processed to pre-miRNA in...

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Detalles Bibliográficos
Autores principales: Yin, Shanye, Yu, Yong, Reed, Robin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4493704/
https://www.ncbi.nlm.nih.gov/pubmed/26149087
http://dx.doi.org/10.1038/srep11992