Cargando…

The destructive effect of botulinum neurotoxins on the SNARE protein: SNAP-25 and synaptic membrane fusion

Synaptic exocytosis requires the assembly of syntaxin 1A and SNAP-25 on the plasma membrane and synaptobrevin 2 (VAMP2) on the vesicular membrane to bridge the two opposite membranes. It is believed that the three SNARE proteins assemble in steps along the dynamic assembly pathway. The C-terminus of...

Descripción completa

Detalles Bibliográficos
Autor principal:	Lu, Bin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	PeerJ Inc. 2015
Materias:	Biochemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4493708/ https://www.ncbi.nlm.nih.gov/pubmed/26157630 http://dx.doi.org/10.7717/peerj.1065

Ejemplares similares

The mesoscale organization of syntaxin 1A and SNAP25 is determined by SNARE–SNARE interactions
por: Mertins, Jasmin, et al.
Publicado: (2021)

A Highly Specific Monoclonal Antibody for Botulinum Neurotoxin Type A-Cleaved SNAP25
por: Rhéaume, Catherine, et al.
Publicado: (2015)

Cleavage of SNAP25 and Its Shorter Versions by the Protease Domain of Serotype A Botulinum Neurotoxin
por: Mizanur, Rahman M., et al.
Publicado: (2014)

Membranes linked by trans-SNARE complexes require lipids prone to non-bilayer structure for progression to fusion
por: Zick, Michael, et al.
Publicado: (2014)

Sec17/Sec18 act twice, enhancing membrane fusion and then disassembling cis-SNARE complexes
por: Song, Hongki, et al.
Publicado: (2017)

Botulinum neurotoxin C mutants reveal different effects of syntaxin or SNAP-25 proteolysis on neuromuscular transmission
por: Zanetti, Giulia, et al.
Publicado: (2017)

High resolution crystal structures of the receptor-binding domain of Clostridium botulinum neurotoxin serotypes A and FA
por: Davies, Jonathan R., et al.
Publicado: (2018)

The t-SNAREs syntaxin 1 and SNAP-25 are present on organelles that participate in synaptic vesicle recycling
Publicado: (1995)

Correction: Membranes linked by trans-SNARE complexes require lipids prone to non-bilayer structure for progression to fusion
por: Zick, Michael, et al.
Publicado: (2015)

Cytotoxicity of Botulinum Neurotoxins Reveals a Direct Role of Syntaxin 1 and SNAP-25 in Neuron Survival
por: Peng, Lisheng, et al.
Publicado: (2013)

Highly Specific Monoclonal Antibody Targeting the Botulinum Neurotoxin Type E Exposed SNAP-25 Neoepitope
por: Mechaly, Adva, et al.
Publicado: (2022)

Distribution of Cleaved SNAP-25 in the Rat Brain, following Unilateral Injection of Botulinum Neurotoxin-A into the Striatum
por: Schümann, Friederike, et al.
Publicado: (2023)

Construction of a Yeast Cell-Based Assay System to Analyze SNAP25-Targeting Botulinum Neurotoxins
por: Chen, Shilin, et al.
Publicado: (2023)

Engineering an Effective Human SNAP-23 Cleaving Botulinum Neurotoxin A Variant
por: Sikorra, Stefan, et al.
Publicado: (2020)

Roles for the SNAP25 linker domain in the fusion pore and a dynamic plasma membrane SNARE “acceptor” complex
por: Holz, Ronald W., et al.
Publicado: (2020)

Optimization of SNAP-25 and VAMP-2 Cleavage by Botulinum Neurotoxin Serotypes A–F Employing Taguchi Design-of-Experiments
por: von Berg, Laura, et al.
Publicado: (2019)

The influence of cell membrane and SNAP25 linker loop on the dynamics and unzipping of SNARE complex
por: Shi, Yi, et al.
Publicado: (2017)

Sec17 (α-SNAP) and an SM-tethering complex regulate the outcome of SNARE zippering in vitro and in vivo
por: Schwartz, Matthew L, et al.
Publicado: (2017)

Towards reconstitution of membrane fusion mediated by SNAREs and other synaptic proteins
por: Brunger, Axel T., et al.
Publicado: (2015)

SM proteins Sly1 and Vps33 co-assemble with Sec17 and SNARE complexes to oppose SNARE disassembly by Sec18
por: Lobingier, Braden T, et al.
Publicado: (2014)

A Label Free Colorimetric Assay for the Detection of Active Botulinum Neurotoxin Type A by SNAP-25 Conjugated Colloidal Gold
por: Halliwell, Jennifer, et al.
Publicado: (2013)

Structural basis for botulinum neurotoxin E recognition of synaptic vesicle protein 2
por: Liu, Zheng, et al.
Publicado: (2023)

Characterization of SNARE Cleavage Products Generated by Formulated Botulinum Neurotoxin Type-A Drug Products
por: Hunt, Terrence, et al.
Publicado: (2010)

SNARE Regulatory Proteins in Synaptic Vesicle Fusion and Recycling
por: Sauvola, Chad W., et al.
Publicado: (2021)

Fusion of tethered membranes can be driven by Sec18/NSF and Sec17/αSNAP without HOPS
por: Song, Hongki, et al.
Publicado: (2021)

Atomic force microscopic image data of botulinum neurotoxin complexes with different molecular sizes
por: Miyashita, Shin-Ichiro, et al.
Publicado: (2019)

The SNARE protein SNAP-25 is required for normal exocytosis at auditory hair cell ribbon synapses
por: Calvet, Charlotte, et al.
Publicado: (2022)

Botulinum Neurotoxin D Uses Synaptic Vesicle Protein SV2 and Gangliosides as Receptors
por: Peng, Lisheng, et al.
Publicado: (2011)

HOPS recognizes each SNARE, assembling ternary trans-complexes for rapid fusion upon engagement with the 4th SNARE
por: Song, Hongki, et al.
Publicado: (2020)

Sec17/Sec18 can support membrane fusion without help from completion of SNARE zippering
por: Song, Hongki, et al.
Publicado: (2021)

Drosophila SNAP-29 Is an Essential SNARE That Binds Multiple Proteins Involved in Membrane Traffic
por: Xu, Hao, et al.
Publicado: (2014)

On Botulinum Neurotoxin Variability
por: Montecucco, Cesare, et al.
Publicado: (2015)

Antipruritic Effects of Botulinum Neurotoxins
por: Gazerani, Parisa
Publicado: (2018)

Functions of the Plant Qbc SNARE SNAP25 in Cytokinesis and Biotic and Abiotic Stress Responses
por: Won, Kang-Hee, et al.
Publicado: (2020)

Botulinum Neurotoxins Can Enter Cultured Neurons Independent of Synaptic Vesicle Recycling
por: Pellett, Sabine, et al.
Publicado: (2015)

Expression of the SNARE Protein SNAP-23 Is Essential for Cell Survival
por: Kaul, Sunil, et al.
Publicado: (2015)

Botulinum Neurotoxin a Blocks Synaptic Vesicle Exocytosis but Not Endocytosis at the Nerve Terminal
por: Neale, Elaine A., et al.
Publicado: (1999)

The Multifaceted Role of SNARE Proteins in Membrane Fusion
por: Han, Jing, et al.
Publicado: (2017)

Membrane Fusion and SNAREs: Interaction with Ras Proteins
por: Margiotta, Azzurra
Publicado: (2022)

Why Are Botulinum Neurotoxin-Producing Bacteria So Diverse and Botulinum Neurotoxins So Toxic?
por: Poulain, Bernard, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_q6a8526fd84hb09fh7ms0bihjs