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Control of the pericentrosomal H(2)O(2) level by peroxiredoxin I is critical for mitotic progression

Proteins associated with the centrosome play key roles in mitotic progression in mammalian cells. The activity of Cdk1-opposing phosphatases at the centrosome must be inhibited during early mitosis to prevent premature dephosphorylation of Cdh1—an activator of the ubiquitin ligase anaphase-promoting...

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Detalles Bibliográficos
Autores principales: Lim, Jung Mi, Lee, Kyung S., Woo, Hyun Ae, Kang, Dongmin, Rhee, Sue Goo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4493999/
https://www.ncbi.nlm.nih.gov/pubmed/26150388
http://dx.doi.org/10.1083/jcb.201412068