The transition zone protein Rpgrip1l regulates proteasomal activity at the primary cilium

Mutations in RPGRIP1L result in severe human diseases called ciliopathies. To unravel the molecular function of RPGRIP1L, we analyzed Rpgrip1l(−/−) mouse embryos, which display a ciliopathy phenotype and die, at the latest, around birth. In these embryos, cilia-mediated signaling was severely distur...

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Detalles Bibliográficos
Autores principales: Gerhardt, Christoph, Lier, Johanna Maria, Burmühl, Stephan, Struchtrup, Andreas, Deutschmann, Kathleen, Vetter, Maik, Leu, Tristan, Reeg, Sandra, Grune, Tilman, Rüther, Ulrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2015
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4494006/
https://www.ncbi.nlm.nih.gov/pubmed/26150391
http://dx.doi.org/10.1083/jcb.201408060

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4494006/
https://www.ncbi.nlm.nih.gov/pubmed/26150391
http://dx.doi.org/10.1083/jcb.201408060

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