Mio depletion links mTOR regulation to Aurora A and Plk1 activation at mitotic centrosomes

Coordination of cell growth and proliferation in response to nutrient supply is mediated by mammalian target of rapamycin (mTOR) signaling. In this study, we report that Mio, a highly conserved member of the SEACAT/GATOR2 complex necessary for the activation of mTORC1 kinase, plays a critical role i...

Descripción completa

Detalles Bibliográficos
Autores principales: Platani, Melpomeni, Trinkle-Mulcahy, Laura, Porter, Michael, Jeyaprakash, A. Arockia, Earnshaw, William C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2015
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4494011/
https://www.ncbi.nlm.nih.gov/pubmed/26124292
http://dx.doi.org/10.1083/jcb.201410001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4494011/
https://www.ncbi.nlm.nih.gov/pubmed/26124292
http://dx.doi.org/10.1083/jcb.201410001

Ejemplares similares