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Pharmacokinetics, pharmacodynamics, and safety of lesinurad, a selective uric acid reabsorption inhibitor, in healthy adult males
Lesinurad is a selective uric acid reabsorption inhibitor under investigation for the treatment of gout. Single and multiple ascending dose studies were conducted to evaluate pharmacokinetics, pharmacodynamics, and safety of lesinurad in healthy males. Lesinurad was administered as an oral solution...
Autores principales: | Shen, Zancong, Rowlings, Colin, Kerr, Brad, Hingorani, Vijay, Manhard, Kimberly, Quart, Barry, Yeh, Li-Tain, Storgard, Chris |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2015
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4494180/ https://www.ncbi.nlm.nih.gov/pubmed/26170627 http://dx.doi.org/10.2147/DDDT.S85193 |
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