Enhanced Efficacy of a Codon-Optimized DNA Vaccine Encoding the Glycoprotein Precursor Gene of Lassa Virus in a Guinea Pig Disease Model When Delivered by Dermal Electroporation

Lassa virus (LASV) causes a severe, often fatal, hemorrhagic fever endemic to West Africa. Presently, there are no FDA-licensed medical countermeasures for this disease. In a pilot study, we constructed a DNA vaccine (pLASV-GPC) that expressed the LASV glycoprotein precursor gene (GPC). This plasmid...

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Detalles Bibliográficos
Autores principales: Cashman, Kathleen A., Broderick, Kate E., Wilkinson, Eric R., Shaia, Carl I., Bell, Todd M., Shurtleff, Amy C., Spik, Kristin W., Badger, Catherine V., Guttieri, Mary C., Sardesai, Niranjan Y., Schmaljohn, Connie S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4494234/
https://www.ncbi.nlm.nih.gov/pubmed/26344112
http://dx.doi.org/10.3390/vaccines1030262

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4494234/
https://www.ncbi.nlm.nih.gov/pubmed/26344112
http://dx.doi.org/10.3390/vaccines1030262

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