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Two novel Brugada syndrome-associated mutations increase K(V)4.3 membrane expression and function
The human cardiac fast transient outward K(+) channel is composed of the K(V)4.3 α subunit encoded by KCND3 and the K(+) channel-interacting protein 2 (KChIP2) β subunit, and determines the early repolarization of the action potential (AP). Two human mutations (G600R and L450F) in K(V)4.3 are associ...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
D.A. Spandidos
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4494594/ https://www.ncbi.nlm.nih.gov/pubmed/26016905 http://dx.doi.org/10.3892/ijmm.2015.2223 |