Selective CNS Uptake of the GCP-II Inhibitor 2-PMPA following Intranasal Administration

Glutamate carboxypeptidase II (GCP-II) is a brain metallopeptidase that hydrolyzes the abundant neuropeptide N-acetyl-aspartyl-glutamate (NAAG) to NAA and glutamate. Small molecule GCP-II inhibitors increase brain NAAG, which activates mGluR3, decreases glutamate, and provide therapeutic utility in...

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Detalles Bibliográficos
Autores principales: Rais, Rana, Wozniak, Krystyna, Wu, Ying, Niwa, Minae, Stathis, Marigo, Alt, Jesse, Giroux, Marc, Sawa, Akira, Rojas, Camilo, Slusher, Barbara S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4494705/
https://www.ncbi.nlm.nih.gov/pubmed/26151906
http://dx.doi.org/10.1371/journal.pone.0131861

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4494705/
https://www.ncbi.nlm.nih.gov/pubmed/26151906
http://dx.doi.org/10.1371/journal.pone.0131861

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