CSN6 deregulation impairs genome integrity in a COP1-dependent pathway

Understanding genome integrity and DNA damage response are critical to cancer treatment. In this study, we identify CSN6's biological function in regulating genome integrity. Constitutive photomorphogenic 1 (COP1), an E3 ubiquitin ligase regulated by CSN6, is downregulated by DNA damage, but th...

Descripción completa

Detalles Bibliográficos
Autores principales: Choi, Hyun Ho, Su, Chun-Hui, Fang, Lekun, Zhang, Jin, Yeung, Sai-Ching J., Lee, Mong-Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Priority Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4494904/
https://www.ncbi.nlm.nih.gov/pubmed/25957415

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4494904/
https://www.ncbi.nlm.nih.gov/pubmed/25957415

Ejemplares similares