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CSN6 deregulation impairs genome integrity in a COP1-dependent pathway

Understanding genome integrity and DNA damage response are critical to cancer treatment. In this study, we identify CSN6's biological function in regulating genome integrity. Constitutive photomorphogenic 1 (COP1), an E3 ubiquitin ligase regulated by CSN6, is downregulated by DNA damage, but th...

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Detalles Bibliográficos
Autores principales:	Choi, Hyun Ho, Su, Chun-Hui, Fang, Lekun, Zhang, Jin, Yeung, Sai-Ching J., Lee, Mong-Hong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2015
Materias:	Priority Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4494904/ https://www.ncbi.nlm.nih.gov/pubmed/25957415

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