Systemic attenuation of the TGF-β pathway by a single drug simultaneously rejuvenates hippocampal neurogenesis and myogenesis in the same old mammal

Stem cell function declines with age largely due to the biochemical imbalances in their tissue niches, and this work demonstrates that aging imposes an elevation in transforming growth factor β (TGF-β) signaling in the neurogenic niche of the hippocampus, analogous to the previously demonstrated cha...

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Detalles Bibliográficos
Autores principales: Yousef, Hanadie, Conboy, Michael J., Morgenthaler, Adam, Schlesinger, Christina, Bugaj, Lukasz, Paliwal, Preeti, Greer, Christopher, Conboy, Irina M., Schaffer, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Gerotarget (Focus on Aging): Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4494916/
https://www.ncbi.nlm.nih.gov/pubmed/26003168

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4494916/
https://www.ncbi.nlm.nih.gov/pubmed/26003168

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