Oncometabolic mutation IDH1 R132H confers a metformin-hypersensitive phenotype

Metabolic flexibility might be particularly constrained in tumors bearing mutations in isocitrate dehydrogenase 1 (IDH1) leading to the production of the oncometabolite 2-hydroxygluratate (2HG). To test the hypothesis that IDH1 mutations could generate metabolic vulnerabilities for therapeutic inter...

Descripción completa

Detalles Bibliográficos
Autores principales: Cuyàs, Elisabet, Fernández-Arroyo, Salvador, Corominas-Faja, Bruna, Rodríguez-Gallego, Esther, Bosch-Barrera, Joaquim, Martin-Castillo, Begoña, De Llorens, Rafael, Joven, Jorge, Menendez, Javier A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4494938/
https://www.ncbi.nlm.nih.gov/pubmed/25980580

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4494938/
https://www.ncbi.nlm.nih.gov/pubmed/25980580

Ejemplares similares