Induction of c-Cbl contributes to anti-cancer effects of HDAC inhibitor in lung cancer

Here we found loss of c-Cbl, an E3 ligase, expression in non-small cell lung cancer (NSCLC) compared with its adjacent normal tissue in patient specimens. HDAC inhibition by WJ or knockdown of HDAC 1, HDAC2, HDAC3 or HDAC6 all induced c-Cbl. Ectopic expression of c-Cbl induced decreased EGFR, inhibi...

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Detalles Bibliográficos
Autores principales: Wei, Tzu-Tang, Lin, Yu-Chin, Lin, Pei-Hua, Shih, Jin-Yuan, Chou, Chia-Wei, Huang, Wei-Jan, Yang, Yu-Chih, Hsiao, Pei-Wen, Chen, Ching-Chow
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4494952/
https://www.ncbi.nlm.nih.gov/pubmed/25980579

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4494952/
https://www.ncbi.nlm.nih.gov/pubmed/25980579

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