Structural basis for allosteric, substrate-dependent stimulation of SIRT1 activity by resveratrol

Sirtuins with an extended N-terminal domain (NTD), represented by yeast Sir2 and human SIRT1, harbor intrinsic mechanisms for regulation of their NAD-dependent deacetylase activities. Elucidation of the regulatory mechanisms is crucial for understanding the biological functions of sirtuins and devel...

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Detalles Bibliográficos
Autores principales: Cao, Duanfang, Wang, Mingzhu, Qiu, Xiayang, Liu, Dongxiang, Jiang, Hualiang, Yang, Na, Xu, Rui-Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4495401/
https://www.ncbi.nlm.nih.gov/pubmed/26109052
http://dx.doi.org/10.1101/gad.265462.115

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4495401/
https://www.ncbi.nlm.nih.gov/pubmed/26109052
http://dx.doi.org/10.1101/gad.265462.115

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