Cargando…

Structural basis for allosteric, substrate-dependent stimulation of SIRT1 activity by resveratrol

Sirtuins with an extended N-terminal domain (NTD), represented by yeast Sir2 and human SIRT1, harbor intrinsic mechanisms for regulation of their NAD-dependent deacetylase activities. Elucidation of the regulatory mechanisms is crucial for understanding the biological functions of sirtuins and devel...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cao, Duanfang, Wang, Mingzhu, Qiu, Xiayang, Liu, Dongxiang, Jiang, Hualiang, Yang, Na, Xu, Rui-Ming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory Press 2015
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4495401/ https://www.ncbi.nlm.nih.gov/pubmed/26109052 http://dx.doi.org/10.1101/gad.265462.115

Ejemplares similares

Mechanism and design of allosteric activators of SIRT1
por: Liu, Fei, et al.
Publicado: (2022)

Sirt1 activation by resveratrol is substrate sequence-selective
por: Lakshminarasimhan, Mahadevan, et al.
Publicado: (2013)

Structural basis for GPR40 allosteric agonism and incretin stimulation
por: Ho, Joseph D., et al.
Publicado: (2018)

Mechanism of allosteric activation of SIRT6 revealed by the action of rationally designed activators
por: Lu, Shaoyong, et al.
Publicado: (2021)

Resveratrol serves as a protein-substrate interaction stabilizer in human SIRT1 activation
por: Hou, Xuben, et al.
Publicado: (2016)

The Structural Basis of ATP as an Allosteric Modulator
por: Lu, Shaoyong, et al.
Publicado: (2014)

SIRT1-dependent mechanisms and effects of resveratrol for amelioration of muscle wasting in NASH mice
por: Liu, Chih-Wei, et al.
Publicado: (2020)

SIRT1-dependent myoprotective effects of resveratrol on muscle injury induced by compression
por: Sin, Thomas K., et al.
Publicado: (2015)

Substrate-Dependent Sensitivity of SIRT1 to Nicotinamide Inhibition
por: Rymarchyk, Stacia, et al.
Publicado: (2021)

Resveratrol and SIRT1: Antiaging Cornerstones for Oocytes?
por: Grzeczka, Arkadiusz, et al.
Publicado: (2022)

Resveratrol-like Compounds as SIRT1 Activators
por: Ciccone, Lidia, et al.
Publicado: (2022)

Resveratrol Induces Vascular Smooth Muscle Cell Differentiation through Stimulation of SirT1 and AMPK
por: Thompson, Anne Marie, et al.
Publicado: (2014)

Radioprotective and Antioxidant Effect of Resveratrol in Hippocampus by Activating Sirt1
por: Li, Jianguo, et al.
Publicado: (2014)

Molecular basis for allosteric agonism and G protein subtype selectivity of galanin receptors
por: Duan, Jia, et al.
Publicado: (2022)

A Novel Mechanism for SIRT1 Activators That Does Not Rely on the Chemical Moiety Immediately C-Terminal to the Acetyl-Lysine of the Substrate
por: Yu, Nian-Da, et al.
Publicado: (2022)

Activation of SIRT1 by Resveratrol requires lamin A
por: Liu, Baohua, et al.
Publicado: (2013)

Structural basis of allosteric regulation of Tel1/ATM kinase
por: Xin, Jiyu, et al.
Publicado: (2019)

Structural basis for allosteric regulation of Human Topoisomerase IIα
por: Vanden Broeck, Arnaud, et al.
Publicado: (2021)

Targeting a cryptic allosteric site of SIRT6 with small-molecule inhibitors that inhibit the migration of pancreatic cancer cells
por: Zhang, Qiufen, et al.
Publicado: (2022)

Depigmenting Effect of Resveratrol Is Dependent on FOXO3a Activation without SIRT1 Activation
por: Kwon, Soon-Hyo, et al.
Publicado: (2017)

Correction: SIRT1-dependent mechanisms and effects of resveratrol for amelioration of muscle wasting in NASH mice
Publicado: (2020)

Activation of Sirt1 by Resveratrol Inhibits TNF-α Induced Inflammation in Fibroblasts
por: Zhu, Xiaoxia, et al.
Publicado: (2011)

Structural basis of redox-dependent substrate binding of protein disulfide isomerase
por: Yagi-Utsumi, Maho, et al.
Publicado: (2015)

Resveratrol Mitigates Sevoflurane-Induced Neurotoxicity by the SIRT1-Dependent Regulation of BDNF Expression in Developing Mice
por: Tang, Xiaole, et al.
Publicado: (2020)

SIRT1-dependent mitochondrial biogenesis supports therapeutic effects of resveratrol against neurodevelopment damage by fluoride
por: Zhao, Qian, et al.
Publicado: (2020)

Neuroprotective Mechanisms of Resveratrol in Alzheimer's Disease: Role of SIRT1
por: Gomes, Bruno Alexandre Quadros, et al.
Publicado: (2018)

Coherent Conformational Degrees of Freedom as a Structural Basis for Allosteric Communication
por: Mitternacht, Simon, et al.
Publicado: (2011)

Structural basis for exploring the allosteric inhibition of human kidney type glutaminase
por: Ramachandran, Sarath, et al.
Publicado: (2016)

The structural basis of the multi-step allosteric activation of Aurora B kinase
por: Segura-Peña, Dario, et al.
Publicado: (2023)

Prefusion structure of human cytomegalovirus glycoprotein B and structural basis for membrane fusion
por: Liu, Yuhang, et al.
Publicado: (2021)

Resveratrol-induced Sirt1 phosphorylation by LKB1 mediates mitochondrial metabolism
por: Huang, Yuanyuan, et al.
Publicado: (2021)

Binding Leverage as a Molecular Basis for Allosteric Regulation
por: Mitternacht, Simon, et al.
Publicado: (2011)

Design, Synthesis, and Biological Evaluation of 8-Mercapto-3,7-Dihydro-1H-Purine-2,6-Diones as Potent Inhibitors of SIRT1, SIRT2, SIRT3, and SIRT5
por: Han, Haozhen, et al.
Publicado: (2020)

Mechanism of hormone and allosteric agonist mediated activation of follicle stimulating hormone receptor
por: Duan, Jia, et al.
Publicado: (2023)

SIRT1-Dependent Upregulation of Antiglycative Defense in HUVECs Is Essential for Resveratrol Protection against High Glucose Stress
por: Santini, Silvano Junior, et al.
Publicado: (2019)

Resveratrol Induced Premature Senescence Is Associated with DNA Damage Mediated SIRT1 and SIRT2 Down-Regulation
por: Kilic Eren, Mehtap, et al.
Publicado: (2015)

Structural basis for electron transport mechanism of complex I-like photosynthetic NAD(P)H dehydrogenase
por: Pan, Xiaowei, et al.
Publicado: (2020)

Resveratrol: brain effects on SIRT1, GPR50 and photoperiodic signaling
por: Leheste, Joerg R., et al.
Publicado: (2015)

Hypoxia: Role of SIRT1 and the protective effect of resveratrol in ovarian function
por: Nishigaki, Akemi, et al.
Publicado: (2021)

Structural Basis for Binding of Allosteric Drug Leads in the Adenosine A(1) Receptor
por: Miao, Yinglong, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_h55fbh34ka389k9njgtct2l6m3