RalB regulates contractility-driven cancer dissemination upon TGFβ stimulation via the RhoGEF GEF-H1

RalA and RalB proteins are key mediators of oncogenic Ras signaling in human oncogenesis. Herein we investigated the mechanistic contribution of Ral proteins to invasion of lung cancer A549 cells after induction of epithelial-mesenchymal transition (EMT) with TGFβ. We show that TGFβ-induced EMT prom...

Descripción completa

Detalles Bibliográficos
Autores principales: Biondini, Marco, Duclos, Guillaume, Meyer-Schaller, Nathalie, Silberzan, Pascal, Camonis, Jacques, Carla Parrini, Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4495419/
https://www.ncbi.nlm.nih.gov/pubmed/26152517
http://dx.doi.org/10.1038/srep11759

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4495419/
https://www.ncbi.nlm.nih.gov/pubmed/26152517
http://dx.doi.org/10.1038/srep11759

Ejemplares similares