Cargando…

RalB regulates contractility-driven cancer dissemination upon TGFβ stimulation via the RhoGEF GEF-H1

RalA and RalB proteins are key mediators of oncogenic Ras signaling in human oncogenesis. Herein we investigated the mechanistic contribution of Ral proteins to invasion of lung cancer A549 cells after induction of epithelial-mesenchymal transition (EMT) with TGFβ. We show that TGFβ-induced EMT prom...

Descripción completa

Detalles Bibliográficos
Autores principales:	Biondini, Marco, Duclos, Guillaume, Meyer-Schaller, Nathalie, Silberzan, Pascal, Camonis, Jacques, Carla Parrini, Maria
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4495419/ https://www.ncbi.nlm.nih.gov/pubmed/26152517 http://dx.doi.org/10.1038/srep11759

Ejemplares similares

Leukemia-associated RhoGEF (LARG) is a novel RhoGEF in cytokinesis and required for the proper completion of abscission
por: Martz, Matthew K., et al.
Publicado: (2013)

I’m coming to GEF you: Regulation of RhoGEFs during cell migration
por: Goicoechea, Silvia M, et al.
Publicado: (2014)

The RhoGEF TEM4 Regulates Endothelial Cell Migration by Suppressing Actomyosin Contractility
por: Mitin, Natalia, et al.
Publicado: (2013)

Tension on JAM-A activates RhoA via GEF-H1 and p115 RhoGEF
por: Scott, David W., et al.
Publicado: (2016)

The RhoGEF DOCK10 is essential for dendritic spine morphogenesis
por: Jaudon, Fanny, et al.
Publicado: (2015)

The Evolutionary Relationship of the Domain Architectures in the RhoGEF-containing Proteins
por: Sun, Qing-Lan, et al.
Publicado: (2005)

Rho GTPase–independent regulation of mitotic progression by the RhoGEF Net1
por: Menon, Sarita, et al.
Publicado: (2013)

Turning Platelets Off and On: Role of RhoGAPs and RhoGEFs in Platelet Activity
por: Comer, Shane P.
Publicado: (2022)

RhoGEF17—An Essential Regulator of Endothelial Cell Death and Growth
por: Weber, Pamina, et al.
Publicado: (2021)

The RGS-RhoGEFs control the amplitude of YAP1 activation by serum
por: Lane, Brandon S., et al.
Publicado: (2021)

Plasma membrane restricted RhoGEF activity is sufficient for RhoA-mediated actin polymerization
por: van Unen, Jakobus, et al.
Publicado: (2015)

Localization of RalB signaling at endomembrane compartments and its modulation by autophagy
por: Singh, Manish Kumar, et al.
Publicado: (2019)

Distinct RhoGEFs Activate Apical and Junctional Contractility under Control of G Proteins during Epithelial Morphogenesis
por: Garcia De Las Bayonas, Alain, et al.
Publicado: (2019)

Prepatterning by RhoGEFs governs Rho GTPase spatiotemporal dynamics during wound repair
por: Nakamura, Mitsutoshi, et al.
Publicado: (2017)

Oncogenic Gαq activates RhoJ through PDZ-RhoGEF
por: Cervantes-Villagrana, Rodolfo Daniel, et al.
Publicado: (2023)

Contributions of the RhoGEF activity of p210 BCR/ABL to disease progression
por: Tala, Ilona, et al.
Publicado: (2012)

A Novel Role for p115RhoGEF in Regulation of Epithelial Plasticity
por: Kher, Swapnil S., et al.
Publicado: (2014)

Characterization and computational simulation of human Syx, a RhoGEF implicated in glioblastoma
por: Boyd, Ryan J., et al.
Publicado: (2022)

Serine phosphorylation of the RhoGEF Trio stabilizes endothelial cell-cell junctions
por: Daniel, Anna E., et al.
Publicado: (2023)

p115RhoGEF activates RhoA to support tight junction maintenance and remodeling
por: Chumki, Shahana A., et al.
Publicado: (2022)

Publisher Correction: Localization of RalB signaling at endomembrane compartments and its modulation by autophagy
por: Singh, Manish Kumar, et al.
Publicado: (2019)

Snail-dependent repression of the RhoGEF pebble is required for gastrulation consistency in Drosophila melanogaster
por: Murray, Michael J., et al.
Publicado: (2012)

Plasma Membrane Association but Not Midzone Recruitment of RhoGEF ECT2 Is Essential for Cytokinesis
por: Kotýnková, Kristýna, et al.
Publicado: (2016)

The COOH-terminal domain of huntingtin interacts with RhoGEF kalirin and modulates cell survival
por: McClory, Hollis, et al.
Publicado: (2018)

Apical polarity proteins recruit the RhoGEF Cysts to promote junctional myosin assembly
por: Silver, Jordan T., et al.
Publicado: (2019)

The potential role of Arhgef33 RhoGEF in foveal development in the zebra finch retina
por: Sugiyama, Takefumi, et al.
Publicado: (2020)

Targeting the RhoGEF βPIX/COOL-1 in Glioblastoma: Proof of Concept Studies
por: Connor, Kate, et al.
Publicado: (2020)

The RhoGEF Trio: A Protein with a Wide Range of Functions in the Vascular Endothelium
por: Kempers, Lanette, et al.
Publicado: (2021)

RalB directly triggers invasion downstream Ras by mobilizing the Wave complex
por: Zago, Giulia, et al.
Publicado: (2018)

Direct interaction of insulin-like growth factor-1 receptor with leukemia-associated RhoGEF
por: Taya, Shinichiro, et al.
Publicado: (2001)

P115 RhoGEF and microtubules decide the direction apoptotic cells extrude from an epithelium
por: Slattum, Gloria, et al.
Publicado: (2009)

The RhoGEF Trio Functions in Sculpting Class Specific Dendrite Morphogenesis in Drosophila Sensory Neurons
por: Iyer, Srividya Chandramouli, et al.
Publicado: (2012)

Regulation of cortical stability by RhoGEF3 in mitotic Sensory Organ Precursor cells in Drosophila
por: Couturier, Lydie, et al.
Publicado: (2017)

PDZ-RhoGEF Is a Signaling Effector for TROY-Induced Glioblastoma Cell Invasion and Survival
por: Ding, Zonghui, et al.
Publicado: (2018)

PAK4 suppresses PDZ-RhoGEF activity to drive invadopodia maturation in melanoma cells
por: Nicholas, Nicole S., et al.
Publicado: (2016)

The Evolutionary Landscape of Dbl-Like RhoGEF Families: Adapting Eukaryotic Cells to Environmental Signals
por: Fort, Philippe, et al.
Publicado: (2017)

RhoGEF Trio Regulates Radial Migration of Projection Neurons via Its Distinct Domains
por: Wei, Chengwen, et al.
Publicado: (2021)

Crystal structures of the PH domains from Lbc family of RhoGEFs bound to activated RhoA GTPase
por: Chen, Zhe, et al.
Publicado: (2018)

Differential involvement of RalA and RalB in colorectal cancer
por: Martin, Timothy D., et al.
Publicado: (2012)

Spatially restricted activation of RhoA at epithelial junctions by p114RhoGEF drives junction formation and morphogenesis
por: Terry, Stephen J., et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_f5gdvao7qgul68g3uter0bq1fu