Crystal Structures of a Hyperthermophilic Archaeal Homoserine Dehydrogenase Suggest a Novel Cofactor Binding Mode for Oxidoreductases

NAD(P)-dependent dehydrogenases differ according to their coenzyme preference: some prefer NAD, others NADP, and still others exhibit dual cofactor specificity. The structure of a newly identified archaeal homoserine dehydrogenase showed this enzyme to have a strong preference for NADP. However, NAD...

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Detalles Bibliográficos
Autores principales: Hayashi, Junji, Inoue, Shota, Kim, Kwang, Yoneda, Kazunari, Kawarabayasi, Yutaka, Ohshima, Toshihisa, Sakuraba, Haruhiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4495429/
https://www.ncbi.nlm.nih.gov/pubmed/26154028
http://dx.doi.org/10.1038/srep11674

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4495429/
https://www.ncbi.nlm.nih.gov/pubmed/26154028
http://dx.doi.org/10.1038/srep11674

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