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Crystal Structures of a Hyperthermophilic Archaeal Homoserine Dehydrogenase Suggest a Novel Cofactor Binding Mode for Oxidoreductases
NAD(P)-dependent dehydrogenases differ according to their coenzyme preference: some prefer NAD, others NADP, and still others exhibit dual cofactor specificity. The structure of a newly identified archaeal homoserine dehydrogenase showed this enzyme to have a strong preference for NADP. However, NAD...
Autores principales: | Hayashi, Junji, Inoue, Shota, Kim, Kwang, Yoneda, Kazunari, Kawarabayasi, Yutaka, Ohshima, Toshihisa, Sakuraba, Haruhiko |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4495429/ https://www.ncbi.nlm.nih.gov/pubmed/26154028 http://dx.doi.org/10.1038/srep11674 |
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