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Structural basis of blocking integrin activation and deactivation for anti-inflammation

Integrins mediate leukocyte accumulation to the sites of inflammation, thereby enhancing their potential as an important therapeutic target for inflammatory disorders. Integrin activation triggered by inflammatory mediators or signaling pathway is a key step to initiate leukocyte migration to inflam...

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Autores principales: Park, Eun Jeong, Yuki, Yoshikazu, Kiyono, Hiroshi, Shimaoka, Motomu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4495637/
https://www.ncbi.nlm.nih.gov/pubmed/26152212
http://dx.doi.org/10.1186/s12929-015-0159-6
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author Park, Eun Jeong
Yuki, Yoshikazu
Kiyono, Hiroshi
Shimaoka, Motomu
author_facet Park, Eun Jeong
Yuki, Yoshikazu
Kiyono, Hiroshi
Shimaoka, Motomu
author_sort Park, Eun Jeong
collection PubMed
description Integrins mediate leukocyte accumulation to the sites of inflammation, thereby enhancing their potential as an important therapeutic target for inflammatory disorders. Integrin activation triggered by inflammatory mediators or signaling pathway is a key step to initiate leukocyte migration to inflamed tissues; however, an appropriately regulated integrin deactivation is indispensable for maintaining productive leukocyte migration. While typical integrin antagonists that block integrin activation target the initiation of leukocyte migration, a novel class of experimental compounds has been designed to block integrin deactivation, thereby perturbing the progression of cell migration. Current review discusses the mechanisms by which integrin is activated and subsequently deactivated by focusing on its structure-function relationship.
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spelling pubmed-44956372015-07-09 Structural basis of blocking integrin activation and deactivation for anti-inflammation Park, Eun Jeong Yuki, Yoshikazu Kiyono, Hiroshi Shimaoka, Motomu J Biomed Sci Review Integrins mediate leukocyte accumulation to the sites of inflammation, thereby enhancing their potential as an important therapeutic target for inflammatory disorders. Integrin activation triggered by inflammatory mediators or signaling pathway is a key step to initiate leukocyte migration to inflamed tissues; however, an appropriately regulated integrin deactivation is indispensable for maintaining productive leukocyte migration. While typical integrin antagonists that block integrin activation target the initiation of leukocyte migration, a novel class of experimental compounds has been designed to block integrin deactivation, thereby perturbing the progression of cell migration. Current review discusses the mechanisms by which integrin is activated and subsequently deactivated by focusing on its structure-function relationship. BioMed Central 2015-07-08 /pmc/articles/PMC4495637/ /pubmed/26152212 http://dx.doi.org/10.1186/s12929-015-0159-6 Text en © Park et al. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Park, Eun Jeong
Yuki, Yoshikazu
Kiyono, Hiroshi
Shimaoka, Motomu
Structural basis of blocking integrin activation and deactivation for anti-inflammation
title Structural basis of blocking integrin activation and deactivation for anti-inflammation
title_full Structural basis of blocking integrin activation and deactivation for anti-inflammation
title_fullStr Structural basis of blocking integrin activation and deactivation for anti-inflammation
title_full_unstemmed Structural basis of blocking integrin activation and deactivation for anti-inflammation
title_short Structural basis of blocking integrin activation and deactivation for anti-inflammation
title_sort structural basis of blocking integrin activation and deactivation for anti-inflammation
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4495637/
https://www.ncbi.nlm.nih.gov/pubmed/26152212
http://dx.doi.org/10.1186/s12929-015-0159-6
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