Global genetic analyses reveal strong inter-ethnic variability in the loss of activity of the organic cation transporter OCT1

BACKGROUND: The organic cation transporter OCT1 (SLC22A1) mediates the uptake of vitamin B1, cationic drugs, and xenobiotics into hepatocytes. Nine percent of Caucasians lack or have very low OCT1 activity due to loss-of-function polymorphisms in OCT1 gene. Here we analyzed the global genetic variab...

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Detalles Bibliográficos
Autores principales: Seitz, Tina, Stalmann, Robert, Dalila, Nawar, Chen, Jiayin, Pojar, Sherin, Dos Santos Pereira, Joao N., Krätzner, Ralph, Brockmöller, Jürgen, Tzvetkov, Mladen V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4495841/
https://www.ncbi.nlm.nih.gov/pubmed/26157489
http://dx.doi.org/10.1186/s13073-015-0172-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4495841/
https://www.ncbi.nlm.nih.gov/pubmed/26157489
http://dx.doi.org/10.1186/s13073-015-0172-0

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