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Cyclo(His-Pro) promotes cytoprotection by activating Nrf2-mediated up-regulation of antioxidant defence

Hystidyl-proline [cyclo(His-Pro)] is an endogenous cyclic dipeptide produced by the cleavage of thyrotropin releasing hormone. Previous studies have shown that cyclo(His-Pro) protects against oxidative stress, although the underlying mechanism has remained elusive. Here, we addressed this issue and...

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Detalles Bibliográficos
Autores principales: Minelli, Alba, Conte, Carmela, Grottelli, Silvia, Bellezza, Maria, Cacciatore, Ivana, Bolaños, Juan P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4496110/
https://www.ncbi.nlm.nih.gov/pubmed/18373731
http://dx.doi.org/10.1111/j.1582-4934.2008.00326.x