Crosstalk between Desmoglein 2 and Patched 1 accelerates chemical-induced skin tumorigenesis

Aberrant activation of Hedgehog (Hh) signaling is causative of BCCs and has been associated with a fraction of SCCs. Desmoglein 2 (Dsg2) is an adhesion protein that is upregulated in many cancers and overexpression of Dsg2 in the epidermis renders mice more susceptible to squamous-derived neoplasia....

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Detalles Bibliográficos
Autores principales: Brennan-Crispi, Donna M., Hossain, Claudia, Sahu, Joya, Brady, Mary, Riobo, Natalia A., Mahoney, Mỹ G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4496169/
https://www.ncbi.nlm.nih.gov/pubmed/25871385

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4496169/
https://www.ncbi.nlm.nih.gov/pubmed/25871385

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