Constitutive asymmetric dimerization drives oncogenic activation of epidermal growth factor receptor carboxyl-terminal deletion mutants

Genomic alterations targeting the Epidermal Growth Factor Receptor (EGFR) gene have been strongly associated with cancer pathogenesis. The clinical effectiveness of EGFR targeted therapies, including small molecules directed against the kinase domain such as gefitinib, erlotinib and afatinib, have b...

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Detalles Bibliográficos
Autores principales: Park, Angela K.J., Francis, Joshua M., Park, Woong-Yang, Park, Joon-Oh, Cho, Jeonghee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4496187/
https://www.ncbi.nlm.nih.gov/pubmed/25826094

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4496187/
https://www.ncbi.nlm.nih.gov/pubmed/25826094

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