Cargando…

Constitutive asymmetric dimerization drives oncogenic activation of epidermal growth factor receptor carboxyl-terminal deletion mutants

Genomic alterations targeting the Epidermal Growth Factor Receptor (EGFR) gene have been strongly associated with cancer pathogenesis. The clinical effectiveness of EGFR targeted therapies, including small molecules directed against the kinase domain such as gefitinib, erlotinib and afatinib, have b...

Descripción completa

Detalles Bibliográficos
Autores principales:	Park, Angela K.J., Francis, Joshua M., Park, Woong-Yang, Park, Joon-Oh, Cho, Jeonghee
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2015
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4496187/ https://www.ncbi.nlm.nih.gov/pubmed/25826094

Ejemplares similares

Autophosphorylation of the carboxyl‐terminal domain is not required for oncogenic transformation by lung‐cancer derived EGFR mutants
por: Cho, Jeonghee, et al.
Publicado: (2018)

Colon cancer-derived oncogenic EGFR G724S mutant identified by whole genome sequence analysis is dependent on asymmetric dimerization and sensitive to cetuximab
por: Cho, Jeonghee, et al.
Publicado: (2014)

Mechanistic insights into differential requirement of receptor dimerization for oncogenic activation of mutant EGFR and its clinical perspective
por: Cho, Jeonghee
Publicado: (2020)

Constitutive activation and oncogenicity are mediated by loss of helical structure at the cytosolic boundary of thrombopoietin receptor mutant dimers
por: Defour, Jean-Philippe, et al.
Publicado: (2023)

Enhanced dimerization drives ligand-independent activity of mutant epidermal growth factor receptor in lung cancer
por: Valley, Christopher C., et al.
Publicado: (2015)

Oncogenic potential of N-terminal deletion and S45Y mutant β-catenin in promoting hepatocellular carcinoma development in mice
por: Qiao, Yu, et al.
Publicado: (2018)

Carboxyl-Terminal Modulator Protein Positively Acts as an Oncogenic Driver in Head and Neck Squamous Cell Carcinoma via Regulating Akt phosphorylation
por: Chang, Jae Won, et al.
Publicado: (2016)

Asymmetric kinase dimer formation is crucial for the activation of oncogenic EGFRvIII but not for ERBB3 phosphorylation
por: Kancha, Rama Krishna, et al.
Publicado: (2013)

Mutational Analysis and Allosteric Effects in the HIV-1 Capsid Protein Carboxyl-Terminal Dimerization Domain
por: Yu, Xiang, et al.
Publicado: (2009)

Integrated genomic approaches identify upregulation of SCRN1 as a novel mechanism associated with acquired resistance to erlotinib in PC9 cells harboring oncogenic EGFR mutation
por: Kim, Nayoung, et al.
Publicado: (2016)

The dimer-dependent catalytic activity of RAF family kinases is revealed through characterizing their oncogenic mutants
por: Yuan, Jimin, et al.
Publicado: (2018)

In Vivo Expression of the PTB-deleted Odin Mutant Results in Hydrocephalus
por: Park, Sunjung, et al.
Publicado: (2015)

The rebel angel: mutant p53 as the driving oncogene in breast cancer
por: Walerych, Dawid, et al.
Publicado: (2012)

Asymmetric dimerization of adenosine deaminase acting on RNA facilitates substrate recognition
por: Thuy-Boun, Alexander S, et al.
Publicado: (2020)

Monoclonal antibody against the fusion junction of a deletion-mutant epidermal growth factor receptor.
por: Okamoto, S., et al.
Publicado: (1996)

Oncogenic CALR mutant C-terminus mediates dual binding to the thrombopoietin receptor triggering complex dimerization and activation
por: Papadopoulos, Nicolas, et al.
Publicado: (2023)

Ligand regulation of a constitutively dimeric EGF receptor
por: Freed, Daniel M., et al.
Publicado: (2015)

Studies of recombinant TWA1 reveal constitutive dimerization
por: Francis, Ore, et al.
Publicado: (2017)

A Possible Role for the Asymmetric C-Terminal Domain Dimer of Rous Sarcoma Virus Integrase in Viral DNA Binding
por: Shi, Ke, et al.
Publicado: (2013)

A peptide interfering with the dimerization of oncogenic KITENIN protein and its stability suppresses colorectal tumour progression
por: Kim, Sung Jin, et al.
Publicado: (2022)

Potentiating Therapeutic Effects of Epidermal Growth Factor Receptor Inhibition in Triple-Negative Breast Cancer
por: You, Kyu Sic, et al.
Publicado: (2021)

Inflammasome, the Constitutive Heterochromatin Machinery, and Replication of an Oncogenic Herpesvirus
por: Bhaduri-McIntosh, Sumita, et al.
Publicado: (2021)

Computation-guided asymmetric total syntheses of resveratrol dimers
por: Nakajima, Masaya, et al.
Publicado: (2022)

Exact Excited-State Functionals of the Asymmetric Hubbard Dimer
por: Giarrusso, Sara, et al.
Publicado: (2023)

Binding of single-mutant epidermal growth factor (EGF) ligands alters the stability of the EGF receptor dimer and promotes growth signaling
por: Pascarelli, Stefano, et al.
Publicado: (2021)

Mutant Oncogenes. Targets for Therapy
por: Børresen, A.-L.
Publicado: (1993)

Whole Transcriptome Analysis Identifies TNS4 as a Key Effector of Cetuximab and a Regulator of the Oncogenic Activity of KRAS Mutant Colorectal Cancer Cell Lines
por: Kim, Sujin, et al.
Publicado: (2019)

Amino- and carboxy-terminal deletion mutants of Gs alpha are localized to the particulate fraction of transfected COS cells
Publicado: (1992)

Nuclear localized Influenza nucleoprotein N-terminal deletion mutant is deficient in functional vRNP formation
por: Sanchez, Abel, et al.
Publicado: (2014)

Coronal Alignment of the Lower Limb and the Incidence of Constitutional Varus Knee in Korean Females
por: Song, Moo-Ho, et al.
Publicado: (2015)

Dermatitis and Aging-Related Barrier Dysfunction in Transgenic Mice Overexpressing an Epidermal-Targeted Claudin 6 Tail Deletion Mutant
por: Troy, Tammy-Claire, et al.
Publicado: (2009)

Dimeric SecA Couples the Preprotein Translocation in an Asymmetric Manner
por: Tang, Ying, et al.
Publicado: (2011)

An Asymmetric Post-Hydrolysis State of the ABC Transporter ATPase Dimer
por: George, Anthony M., et al.
Publicado: (2013)

Heat shock protein 70-mediated sensitization of cells to apoptosis by Carboxyl-Terminal Modulator Protein
por: Piao, Longzhen, et al.
Publicado: (2009)

Crystal structure of the N-terminal domain of MinC dimerized via domain swapping
por: An, Jun Yop, et al.
Publicado: (2013)

Errata to "Coronal Alignment of the Lower Limb and the Incidence of Constitutional Varus Knee in Korean Females"
por: Song, Moo-Ho, et al.
Publicado: (2015)

Constitutive activation of oncogenic PDGFRα-mutant proteins occurring in GIST patients induces receptor mislocalisation and alters PDGFRα signalling characteristics
por: Bahlawane, Christelle, et al.
Publicado: (2015)

Expression of the oncogenic, constitutive active Platelet-Derived Growth Factor Receptor alpha D842V mutant induces loss of primary cilia
por: Nielsen, BS, et al.
Publicado: (2015)

Wing Defects in Drosophila xenicid Mutant Clones Are Caused by C-Terminal Deletion of Additional Sex Combs (Asx)
por: Bischoff, Kara, et al.
Publicado: (2009)

Myeloid lineage enhancers drive oncogene synergy in CEBPA/CSF3R mutant acute myeloid leukemia
por: Braun, Theodore P., et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_7icslkeavmuagal7di6htr7a57