GSK3 is required for rapalogs to induce degradation of some oncogenic proteins and to suppress cancer cell growth

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The single-agent activity of rapalogs (rapamycin and its analogues) in most tumor types has been modest at best. The underlying mechanisms are largely unclear. In this report, we have uncovered a critical role of GSK3 in regulating degradation of some oncogenic proteins induced by rapalogs and cell...

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Detalles Bibliográficos
Autores principales: Koo, Junghui, Wang, Xuerong, Owonikoko, Taofeek K., Ramalingam, Suresh S., Khuri, Fadlo R., Sun, Shi-Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4496196/
https://www.ncbi.nlm.nih.gov/pubmed/25797247

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4496196/
https://www.ncbi.nlm.nih.gov/pubmed/25797247

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