Shp2 SUMOylation promotes ERK activation and hepatocellular carcinoma development

Shp2, an ubiquitously expressed protein tyrosine phosphatase, is essential for regulation of Ras/ERK signaling pathway and tumorigenesis. Here we report that Shp2 is modified by SUMO1 at lysine residue 590 (K(590)) in its C-terminus, which is reduced by SUMO1-specific protease SENP1. Analysis of wil...

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Detalles Bibliográficos
Autores principales: Deng, Rong, Zhao, Xian, Qu, YingYing, Chen, Cheng, Zhu, Changhong, Zhang, Hailong, Yuan, Haihua, Jin, Hui, Liu, Xin, Wang, Yanli, Chen, Qin, Huang, Jian, Yu, Jianxiu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4496222/
https://www.ncbi.nlm.nih.gov/pubmed/25823821

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4496222/
https://www.ncbi.nlm.nih.gov/pubmed/25823821

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