Urocortin3 mediates somatostatin-dependent negative feedback control of insulin secretion

The peptide hormone Urocortin3 (Ucn3) is abundantly expressed by mature beta cells, yet its physiological role is unknown. Here we demonstrate that Ucn3 is stored and co–released with insulin and potentiates glucose–stimulated somatostatin secretion via cognate receptor on delta cells. Further, we f...

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Detalles Bibliográficos
Autores principales: van der Meulen, Talitha, Donaldson, Cynthia J., Cáceres, Elena, Hunter, Anna E., Cowing–Zitron, Christopher, Pound, Lynley D., Adams, Michael W., Zembrzycki, Andreas, Grove, Kevin L., Huising, Mark O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4496282/
https://www.ncbi.nlm.nih.gov/pubmed/26076035
http://dx.doi.org/10.1038/nm.3872

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4496282/
https://www.ncbi.nlm.nih.gov/pubmed/26076035
http://dx.doi.org/10.1038/nm.3872

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