Selective enhancement of endothelial BMPR-II with BMP9 reverses pulmonary arterial hypertension

Genetic evidence implicates the loss of bone morphogenetic protein type II receptor (BMPR-II) signaling in the endothelium as an initiating factor in pulmonary arterial hypertension (PAH). However, selective targeting of this signaling pathway using BMP ligands has not yet been explored as a therape...

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Detalles Bibliográficos
Autores principales: Long, Lu, Ormiston, Mark L., Yang, Xudong, Southwood, Mark, Gräf, Stefan, Machado, Rajiv D., Mueller, Matthias, Kinzel, Bernd, Yung, Lai Ming, Wilkinson, Janine M., Moore, Stephen D., Drake, Kylie M., Aldred, Micheala A., Yu, Paul, Upton, Paul D., Morrell, Nicholas W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4496295/
https://www.ncbi.nlm.nih.gov/pubmed/26076038
http://dx.doi.org/10.1038/nm.3877

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4496295/
https://www.ncbi.nlm.nih.gov/pubmed/26076038
http://dx.doi.org/10.1038/nm.3877

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