Potentiating the cellular targeting and anti-tumor activity of Dp44mT via binding to human serum albumin: two saturable mechanisms of Dp44mT uptake by cells

Di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT) demonstrates potent anti-cancer activity. We previously demonstrated that (14)C-Dp44mT enters and targets cells through a carrier/receptor-mediated uptake process. Despite structural similarity, 2-benzoylpyridine 4-ethyl-3-thiosemicarbazon...

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Detalles Bibliográficos
Autores principales: Merlot, Angelica M., Sahni, Sumit, Lane, Darius J.R., Fordham, Ashleigh M., Pantarat, Namfon, Hibbs, David E., Richardson, Vera, Doddareddy, Munikumar R., Ong, Jennifer A., Huang, Michael L.H., Richardson, Des R., Kalinowski, Danuta S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4496362/
https://www.ncbi.nlm.nih.gov/pubmed/25848850

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4496362/
https://www.ncbi.nlm.nih.gov/pubmed/25848850

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