Cargando…

Potentiating the cellular targeting and anti-tumor activity of Dp44mT via binding to human serum albumin: two saturable mechanisms of Dp44mT uptake by cells

Di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT) demonstrates potent anti-cancer activity. We previously demonstrated that (14)C-Dp44mT enters and targets cells through a carrier/receptor-mediated uptake process. Despite structural similarity, 2-benzoylpyridine 4-ethyl-3-thiosemicarbazon...

Descripción completa

Detalles Bibliográficos
Autores principales:	Merlot, Angelica M., Sahni, Sumit, Lane, Darius J.R., Fordham, Ashleigh M., Pantarat, Namfon, Hibbs, David E., Richardson, Vera, Doddareddy, Munikumar R., Ong, Jennifer A., Huang, Michael L.H., Richardson, Des R., Kalinowski, Danuta S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2015
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4496362/ https://www.ncbi.nlm.nih.gov/pubmed/25848850

Ejemplares similares

Letter to the Editor: “Analysis of the Interaction of Dp44mT with Human Serum Albumin and Calf Thymus DNA Using Molecular Docking and Spectroscopic Techniques”
por: Merlot, Angelica M., et al.
Publicado: (2016)

A mechanism for overcoming P-glycoprotein-mediated drug resistance: novel combination therapy that releases stored doxorubicin from lysosomes via lysosomal permeabilization using Dp44mT or DpC
por: Seebacher, Nicole A, et al.
Publicado: (2016)

Copper-Catalyzed Glutathione Oxidation is Accelerated by the Anticancer Thiosemicarbazone Dp44mT and Further Boosted at Lower pH
por: Falcone, Enrico, et al.
Publicado: (2022)

Analysis of the Interaction of Dp44mT with Human Serum Albumin and Calf Thymus DNA Using Molecular Docking and Spectroscopic Techniques
por: Xu, Zhongjie, et al.
Publicado: (2016)

The Iron Chelator, Dp44mT, Effectively Inhibits Human Oral Squamous Cell Carcinoma Cell Growth in Vitro and in Vivo
por: Lee, Jehn-Chuan, et al.
Publicado: (2016)

Dp44mT targets the AKT, TGF-β and ERK pathways via the metastasis suppressor NDRG1 in normal prostate epithelial cells and prostate cancer cells
por: Dixon, K M, et al.
Publicado: (2013)

Editorial: Analysis of the Interaction of Dp44mT with Human Serum Albumin and Calf Thymus DNA Using Molecular Docking and Spectroscopic Techniques
por: Drummen, Gregor P. C., et al.
Publicado: (2016)

Dp44mT regulates the levels of inflammatory mediators through blocking NF-κB nuclear translocation in LPS-stimulated RAW 264.7 macrophages
por: Lim, Jin-Ho, et al.
Publicado: (2021)

Response to the Letter to the Editor by D. Richardson: Analysis of the Interaction of Dp44mT with Human Serum Albumin and Calf Thymus DNA Using Molecular Docking and Spectroscopic Techniques
por: Xu, Zhongjie, et al.
Publicado: (2016)

The iron chelator Dp44mT inhibits hepatocellular carcinoma metastasis via N-Myc downstream-regulated gene 2 (NDRG2)/gp130/STAT3 pathway
por: Wang, Jiabei, et al.
Publicado: (2014)

Correction: Zhongjie Xu, et al. Analysis of the Interaction of Dp44mT with Human Serum Albumin and Calf Thymus DNA using Molecular Docking and Spectroscopic Techniques. Int. J. Mol. Sci. 2016, 17, 1042
por: Xu, Zhongjie, et al.
Publicado: (2016)

Long non-coding RNA MT1DP shunts the cellular defense to cytotoxicity through crosstalk with MT1H and RhoC in cadmium stress
por: Gao, Ming, et al.
Publicado: (2018)

Safety evaluation of the food enzyme α‐amylase from Bacillus licheniformis (strain DP‐Dzb44)
por: Silano, Vittorio, et al.
Publicado: (2019)

The novel thiosemicarbazone, di-2-pyridylketone 4-cyclohexyl-4-methyl-3-thiosemicarbazone (DpC), inhibits neuroblastoma growth in vitro and in vivo via multiple mechanisms
por: Guo, Zhu-Ling, et al.
Publicado: (2016)

Inhibition of the prostaglandin D(2)–GPR44/DP2 axis improves human islet survival and function
por: Abadpour, Shadab, et al.
Publicado: (2020)

Trigger & DP 1/2
por: Boyd, Jamie
Publicado: (2011)

Trigger & DP 2/2
por: Boyd, Jamie
Publicado: (2011)

Unraveling the mysteries of serum albumin—more than just a serum protein
por: Merlot, Angelica M., et al.
Publicado: (2014)

Rescue of Defective Electroretinographic Responses in Dp71-Null Mice With AAV-Mediated Reexpression of Dp71
por: Barboni, Mirella Telles Salgueiro, et al.
Publicado: (2020)

Clinical Clues to Differentiate between Dermatophyte Onychomycosis (DP-OM) and Dermatophytoma-Like Traumatic Onychodystrophy (DP-TO)
por: Bunyaratavej, Sumanas, et al.
Publicado: (2022)

LncRNA MT1DP Aggravates Cadmium‐Induced Oxidative Stress by Repressing the Function of Nrf2 and is Dependent on Interaction with miR‐365
por: Gao, Ming, et al.
Publicado: (2018)

Predictions for $m_t$ and $M_W$ in Minimal Supersymmetric Models
por: Buchmueller, O., et al.
Publicado: (2009)

Dp71 Expression in Human Glioblastoma
por: Ruggieri, Simona, et al.
Publicado: (2019)

Reply to Lao Q and Merke DP
por: Baumgartner-Parzer, Sabina, et al.
Publicado: (2021)

Dp-ucMGP as a Biomarker in Sarcopenia
por: Schweighofer, Natascha, et al.
Publicado: (2022)

Deletion of DP148R, DP71L, and DP96R Attenuates African Swine Fever Virus, and the Mutant Strain Confers Complete Protection against Homologous Challenges in Pigs
por: Qi, Xiaolan, et al.
Publicado: (2023)

Effect of Epoxy Adhesive on Nugget Formation in Resistance Welding of SAE1004/DP600/DP780 Steel Sheets
por: Zhao, Yixi, et al.
Publicado: (2018)

Generation and characterization of an antagonistic monoclonal antibody against an extracellular domain of mouse DP2 (CRTH2/GPR44) receptors for prostaglandin D(2)
por: Nagata, Nanae, et al.
Publicado: (2017)

Association of variants m.T16172C and m.T16519C in whole mtDNA sequences with high altitude pulmonary edema in Han Chinese lowlanders
por: Wang, Yan, et al.
Publicado: (2022)

Digital circuitry for the digitized protractor DP3
por: Evershed, B W
Publicado: (1961)

The complete experiment for backward elastic dp scattering
por: Rekalo, M P, et al.
Publicado: (1996)

PROFIBUS-DP to G-64 configurable interface
por: Carlier, E, et al.
Publicado: (2001)

SOCS-3 Inhibits E2F/DP-1 Transcriptional Activity and Cell Cycle Progression via Interaction with DP-1
por: Masuhiro, Yoshikazu, et al.
Publicado: (2008)

Prostaglandin D(2) effects and DP (1)/DP (2) receptor distribution in guinea pig urinary bladder out‐flow region
por: Guan, Na N., et al.
Publicado: (2016)

Structure of the DP1–DP2 PolD complex bound with DNA and its implications for the evolutionary history of DNA and RNA polymerases
por: Raia, Pierre, et al.
Publicado: (2019)

Complete Genome Sequence of Pseudomonas aeruginosa Phage vB_PaeM_CEB_DP1
por: Pires, Diana P., et al.
Publicado: (2015)

Effect of thioridazine on antioxidant status of HEMn-DP melanocytes
por: Otręba, Michał, et al.
Publicado: (2015)

Extracellular Polyhydroxyalkanoate Depolymerase by Acidovorax sp. DP5
por: Vigneswari, S., et al.
Publicado: (2015)

Visualizing Molecular Profiles of Glioblastoma with GBM-BioDP
por: Celiku, Orieta, et al.
Publicado: (2014)

Evidence of the involvement of dystrophin Dp71 in corneal angiogenesis
por: Ortiz, Gabriella, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_2mh6l2cefmll7f7kqqit4dm88d