PI3K pan-inhibition impairs more efficiently proliferation and survival of T-cell acute lymphoblastic leukemia cell lines when compared to isoform-selective PI3K inhibitors

Class I phosphatidylinositol 3-kinases (PI3Ks) are frequently activated in T-cell acute lymphoblastic leukemia (T-ALL), mainly due to the loss of PTEN function. Therefore, targeting PI3Ks is a promising innovative approach for T-ALL treatment, however at present no definitive evidence indicated whic...

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Detalles Bibliográficos
Autores principales: Lonetti, Annalisa, Cappellini, Alessandra, Spartà, Antonino Maria, Chiarini, Francesca, Buontempo, Francesca, Evangelisti, Camilla, Evangelisti, Cecilia, Orsini, Ester, McCubrey, James A., Martelli, Alberto Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4496363/
https://www.ncbi.nlm.nih.gov/pubmed/25871383

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4496363/
https://www.ncbi.nlm.nih.gov/pubmed/25871383

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