HDACi inhibits liposarcoma via targeting of the MDM2-p53 signaling axis and PTEN, irrespective of p53 mutational status

The MDM2-p53 pathway plays a prominent role in well-differentiated liposarcoma (LPS) pathogenesis. Here, we explore the importance of MDM2 amplification and p53 mutation in LPS independently, to determine whether HDACi are therapeutically useful in LPS. We demonstrated that simultaneous knockdown of...

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Detalles Bibliográficos
Autores principales: Ou, Wen-Bin, Zhu, Jiaqing, Eilers, Grant, Li, Xuhui, Kuang, Ye, Liu, Li, Mariño-Enríquez, Adrián, Yan, Ziqin, Li, Hailong, Meng, Fanguo, Zhou, Haimeng, Sheng, Qing, Fletcher, Jonathan A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4496371/
https://www.ncbi.nlm.nih.gov/pubmed/25888633

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4496371/
https://www.ncbi.nlm.nih.gov/pubmed/25888633

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