NGF-induced TrkA/CD44 association is involved in tumor aggressiveness and resistance to lestaurtinib

There is accumulating evidence that TrkA and its ligand Nerve Growth Factor (NGF) are involved in cancer development. Staurosporine derivatives such as K252a and lestaurtinib have been developed to block TrkA kinase signaling, but no clinical trial has fully demonstrated their therapeutic efficacy....

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Detalles Bibliográficos
Autores principales: Aubert, Léo, Guilbert, Matthieu, Corbet, Cyril, Génot, Elisabeth, Adriaenssens, Eric, Chassat, Thierry, Bertucci, François, Daubon, Thomas, Magné, Nicolas, Le Bourhis, Xuefen, Toillon, Robert-Alain
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4496399/
https://www.ncbi.nlm.nih.gov/pubmed/25840418

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4496399/
https://www.ncbi.nlm.nih.gov/pubmed/25840418

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