Cargando…

Radiosynthesis, In Vivo Biological Evaluation, and Imaging of Brain Lesions with [(123)I]-CLINME, a New SPECT Tracer for the Translocator Protein

The high affinity translocator protein (TSPO) ligand 6-chloro-2-(4′-iodophenyl)-3-(N,N-methylethyl)imidazo[1,2-a]pyridine-3-acetamide (CLINME) was radiolabelled with iodine-123 and assessed for its sensitivity for the TSPO in rodents. Moreover neuroinflammatory changes on a unilateral excitotoxic le...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mattner, F., Quinlivan, M., Greguric, I., Pham, T., Liu, X., Jackson, T., Berghofer, P., Fookes, C. J. R., Dikic, B., Gregoire, M.-C., Dolle, F., Katsifis, A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4496498/ https://www.ncbi.nlm.nih.gov/pubmed/26199457 http://dx.doi.org/10.1155/2015/729698

Ejemplares similares

Synthesis and biological characterisation of (18)F-SIG343 and (18)F-SIG353, novel and high selectivity σ(2) radiotracers, for tumour imaging properties
por: Nguyen, Vu H, et al.
Publicado: (2013)

One-Pot Radiosynthesis and Biological Evaluation of a Caspase-3 Selective 5-[(123,125)I]iodo-1,2,3-triazole derived Isatin SPECT Tracer
por: Glaser, Matthias, et al.
Publicado: (2019)

[(123)I]-Celecoxib Analogues as SPECT Tracers of Cyclooxygenase-2 in Inflammation
por: Uddin, Md. Jashim, et al.
Publicado: (2010)

PET imaging of brain inflammation during early epileptogenesis in a rat model of temporal lobe epilepsy
por: Dedeurwaerdere, Stefanie, et al.
Publicado: (2012)

GMP-Compliant Radiosynthesis of [(18)F]GP1, a Novel PET Tracer for the Detection of Thrombi
por: Hugenberg, Verena, et al.
Publicado: (2021)

Determination of radionuclides and radiochemical impurities produced by in-house cyclotron irradiation and subsequent radiosynthesis of PET tracers
por: Ishiwata, Kiichi, et al.
Publicado: (2016)

Protocols for Dual Tracer PET/SPECT Preclinical Imaging
por: Blower, Julia E., et al.
Publicado: (2020)

Radiosynthesis of [(11)C]SNAP-7941—the first PET-tracer for the melanin concentrating hormone receptor 1 (MCHR1)
por: Philippe, C., et al.
Publicado: (2012)

Radiosynthesis and Biological Evaluation of N-[(18)F]Labeled Glutamic Acid as a Tumor Metabolic Imaging Tracer
por: Hu, Kongzhen, et al.
Publicado: (2014)

Radiosynthesis and Preliminary Biological Evaluation of (18)F-Fluoropropionyl-Chlorotoxin as a Potential PET Tracer for Glioma Imaging
por: Zhao, Jing, et al.
Publicado: (2018)

Radiosynthesis of the norepinephrine transporter tracer [(18)F]NS12137 via copper‐mediated (18) F‐labelling
por: Lahdenpohja, Salla, et al.
Publicado: (2019)

Radiosynthesis and validation of (±)-[(18)F]-3-fluoro-2-hydroxypropionate ([(18)F]-FLac) as a PET tracer of lactate to monitor MCT1-dependent lactate uptake in tumors
por: Van Hée, Vincent F., et al.
Publicado: (2017)

The SPECT tracer [(123)I]ADAM binds selectively to serotonin transporters: a double-blind, placebo-controlled study in healthy young men
por: van de Giessen, Elsmarieke, et al.
Publicado: (2010)

Radiosynthesis and preliminary biological evaluation of N-(2-[(18)F]fluoropropionyl)-L-glutamine as a PET tracer for tumor imaging
por: Tang, Caihua, et al.
Publicado: (2016)

Patient-specific tracer activity in MPI SPECT: A hands-on approach
por: van Dijk, J. D., et al.
Publicado: (2015)

Targeted design of a recombinant tracer for SPECT renal imaging
por: Liu, Pan, et al.
Publicado: (2021)

High-yielding (18)F radiosynthesis of a novel oxytocin receptor tracer, a probe for nose-to-brain oxytocin uptake in vivo
por: Beard, Rhiannon, et al.
Publicado: (2018)

Fully-automated radiosynthesis of the amyloid tracer [(11)C] PiB via direct [(11)C]CO(2) fixation-reduction
por: Buccino, Pablo, et al.
Publicado: (2019)

Radiosynthesis and in vivo evaluation of (11)C-labeled BMS-193885 and its desmethyl analog as PET tracers for neuropeptide Y1 receptors
por: Kawamura, Kazunori, et al.
Publicado: (2019)

Clinicopathological and (123)I‐FP‐CIT SPECT correlations in patients with dementia
por: Jung, Youngsin, et al.
Publicado: (2018)

CT-Based Attenuation Correction in I-123-Ioflupane SPECT
por: Lange, Catharina, et al.
Publicado: (2014)

Radiosynthesis of 5-[(18)F]Fluoro-1,2,3-triazoles through Aqueous Iodine–[(18)F]Fluorine Exchange Reaction
por: Zhang, Xiang, et al.
Publicado: (2021)

Radiosynthesis and in vivo evaluation of two imidazopyridineacetamides, [(11)C]CB184 and [(11)C]CB190, as a PET tracer for 18 kDa translocator protein: direct comparison with [(11)C](R)-PK11195
por: Hatano, Kentaro, et al.
Publicado: (2015)

Radioiodinated Phenylalkyl Malonic Acid Derivatives as pH-Sensitive SPECT Tracers
por: Bauwens, Matthias, et al.
Publicado: (2012)

A New Method for Radiosynthesis of (11)C-Labeled Carbamate Groups and its Application for a Highly Efficient Synthesis of the Kappa-Opioid Receptor Tracer [(11)C]GR103545
por: Schoultz, B.W, et al.
Publicado: (2008)

Imaging of serotonin transporters with [(123)I]FP-CIT SPECT in the human hypothalamus
por: Borgers, Anke J, et al.
Publicado: (2013)

Focal (123)I-FP-CIT SPECT Abnormality in Midbrain Vascular Parkinsonism
por: Solla, Paolo, et al.
Publicado: (2015)

Japanese multicenter database of healthy controls for [(123)I]FP-CIT SPECT
por: Matsuda, Hiroshi, et al.
Publicado: (2018)

Characterization of Rhodamine-123 as a Tracer Dye for Use In In vitro Drug Transport Assays
por: Forster, Samantha, et al.
Publicado: (2012)

(123)I-ioflupane brain SPECT and (123)I-MIBG cardiac planar scintigraphy combined use in uncertain parkinsonian disorders
por: Nuvoli, Susanna, et al.
Publicado: (2017)

Radiosynthesis of [(18)F]-Labelled Pro-Nucleotides (ProTides)
por: Cavaliere, Alessandra, et al.
Publicado: (2020)

Radiosynthesis of [(18)F]Trifluoroalkyl Groups: Scope and Limitations
por: Lien, V. T., et al.
Publicado: (2014)

Improved Automated Radiosynthesis of [(11)C]PBR28
por: Solingapuram Sai, Kiran Kumar, et al.
Publicado: (2015)

Radiosynthesis and reactivity of N-[(11)C]methyl carbamoylimidazole
por: Kadirvel, Manikandan, et al.
Publicado: (2018)

An updated radiosynthesis of [(18)F]AV1451 for tau PET imaging
por: Mossine, Andrew V., et al.
Publicado: (2017)

Evaluation of pulmonary perfusion by SPECT imaging using an endothelial cell tracer in supine humans and dogs
por: Levac, Xavier, et al.
Publicado: (2016)

Simultaneous in vivo imaging with PET and SPECT tracers using a Compton-PET hybrid camera
por: Uenomachi, Mizuki, et al.
Publicado: (2021)

Altered SPECT (123)I-iomazenil Binding in the Cingulate Cortex of Children with Anorexia Nervosa
por: Nagamitsu, Shinichiro, et al.
Publicado: (2016)

Discriminating among degenerative parkinsonisms using advanced (123)I-ioflupane SPECT analyses
por: Badoud, Simon, et al.
Publicado: (2016)

Midventricular Takotsubo Cardiomyopathy on (99m)Tc-tetrofosmin and (123)I-BMIPP SPECT
por: Ito, Shimpei, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_u6hrjnl60mtnrhpe9s2j3ek36a