Opioid-induced secondary adrenal insufficiency presenting as hypercalcaemia

Adrenal insufficiency is a rare cause of hypercalcaemia and should be considered when more common causes such as primary hyperparathyroidism and malignancy are excluded. Opioid therapy as a cause of adrenal insufficiency is a possibly under-recognised endocrinopathy with potentially life-threatening...

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Autores principales: Lee, Angela S, Twigg, Stephen M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bioscientifica Ltd 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4496564/
https://www.ncbi.nlm.nih.gov/pubmed/26161260
http://dx.doi.org/10.1530/EDM-15-0035
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author Lee, Angela S
Twigg, Stephen M
author_facet Lee, Angela S
Twigg, Stephen M
author_sort Lee, Angela S
collection PubMed
description Adrenal insufficiency is a rare cause of hypercalcaemia and should be considered when more common causes such as primary hyperparathyroidism and malignancy are excluded. Opioid therapy as a cause of adrenal insufficiency is a possibly under-recognised endocrinopathy with potentially life-threatening adverse effects. We report on a case of opioid-induced secondary adrenal insufficiency presenting as hypercalcaemia. The patient was a 25-year-old man who developed hypercalcaemia during the recovery stage after a period of critical illness. Systematic investigation of his hypercalcaemia found it to be due to secondary adrenal insufficiency, developing as a consequence of methadone opioid analgesia. Treatment with i.v. saline and subsequent glucocorticoid replacement led to resolution of the hypercalcaemia. The hypoadrenalism resolved when opioids were subsequently weaned and ceased. These two interacting endocrinopathies of opioid-induced adrenal insufficiency and consequent hypercalcaemia highlight the importance of maintaining awareness of the potentially serious adverse clinical outcomes which can occur as a result of opioids, particularly considering that symptoms of hypoadrenalism can overlap with those of concomitant illness. Treatment with hydration and glucocorticoid replacement is effective in promptly resolving the hypercalcaemia due to hypoadrenalism. Hypoadrenalism due to prescribed and recreational opioids may be more common than is currently recognised. LEARNING POINTS: Opioid therapy can cause clinically significant secondary adrenal insufficiency, and this may be more common than is currently recognised. Adrenal insufficiency is reversible after discontinuation of the opioid therapy. Hypercalcaemia can occur as a consequence of adrenal insufficiency, and may be the presenting feature. Treatment of hypercalcaemia due to adrenal insufficiency involves i.v. saline and glucocorticoid replacement.
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spelling pubmed-44965642015-07-09 Opioid-induced secondary adrenal insufficiency presenting as hypercalcaemia Lee, Angela S Twigg, Stephen M Endocrinol Diabetes Metab Case Rep Unusual Effects of Medical Treatment Adrenal insufficiency is a rare cause of hypercalcaemia and should be considered when more common causes such as primary hyperparathyroidism and malignancy are excluded. Opioid therapy as a cause of adrenal insufficiency is a possibly under-recognised endocrinopathy with potentially life-threatening adverse effects. We report on a case of opioid-induced secondary adrenal insufficiency presenting as hypercalcaemia. The patient was a 25-year-old man who developed hypercalcaemia during the recovery stage after a period of critical illness. Systematic investigation of his hypercalcaemia found it to be due to secondary adrenal insufficiency, developing as a consequence of methadone opioid analgesia. Treatment with i.v. saline and subsequent glucocorticoid replacement led to resolution of the hypercalcaemia. The hypoadrenalism resolved when opioids were subsequently weaned and ceased. These two interacting endocrinopathies of opioid-induced adrenal insufficiency and consequent hypercalcaemia highlight the importance of maintaining awareness of the potentially serious adverse clinical outcomes which can occur as a result of opioids, particularly considering that symptoms of hypoadrenalism can overlap with those of concomitant illness. Treatment with hydration and glucocorticoid replacement is effective in promptly resolving the hypercalcaemia due to hypoadrenalism. Hypoadrenalism due to prescribed and recreational opioids may be more common than is currently recognised. LEARNING POINTS: Opioid therapy can cause clinically significant secondary adrenal insufficiency, and this may be more common than is currently recognised. Adrenal insufficiency is reversible after discontinuation of the opioid therapy. Hypercalcaemia can occur as a consequence of adrenal insufficiency, and may be the presenting feature. Treatment of hypercalcaemia due to adrenal insufficiency involves i.v. saline and glucocorticoid replacement. Bioscientifica Ltd 2015-06-18 2015 /pmc/articles/PMC4496564/ /pubmed/26161260 http://dx.doi.org/10.1530/EDM-15-0035 Text en © 2015 The authors This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.en_GB) .
spellingShingle Unusual Effects of Medical Treatment
Lee, Angela S
Twigg, Stephen M
Opioid-induced secondary adrenal insufficiency presenting as hypercalcaemia
title Opioid-induced secondary adrenal insufficiency presenting as hypercalcaemia
title_full Opioid-induced secondary adrenal insufficiency presenting as hypercalcaemia
title_fullStr Opioid-induced secondary adrenal insufficiency presenting as hypercalcaemia
title_full_unstemmed Opioid-induced secondary adrenal insufficiency presenting as hypercalcaemia
title_short Opioid-induced secondary adrenal insufficiency presenting as hypercalcaemia
title_sort opioid-induced secondary adrenal insufficiency presenting as hypercalcaemia
topic Unusual Effects of Medical Treatment
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4496564/
https://www.ncbi.nlm.nih.gov/pubmed/26161260
http://dx.doi.org/10.1530/EDM-15-0035
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