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Seeking a Mechanism for the Toxicity of Oligomeric α-Synuclein
In a number of neurological diseases including Parkinson’s disease (PD), α‑synuclein is aberrantly folded, forming abnormal oligomers, and amyloid fibrils within nerve cells. Strong evidence exists for the toxicity of increased production and aggregation of α-synuclein in vivo. The toxicity of α-syn...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4496673/ https://www.ncbi.nlm.nih.gov/pubmed/25816357 http://dx.doi.org/10.3390/biom5020282 |
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author | Roberts, Hazel L. Brown, David R. |
author_facet | Roberts, Hazel L. Brown, David R. |
author_sort | Roberts, Hazel L. |
collection | PubMed |
description | In a number of neurological diseases including Parkinson’s disease (PD), α‑synuclein is aberrantly folded, forming abnormal oligomers, and amyloid fibrils within nerve cells. Strong evidence exists for the toxicity of increased production and aggregation of α-synuclein in vivo. The toxicity of α-synuclein is popularly attributed to the formation of “toxic oligomers”: a heterogenous and poorly characterized group of conformers that may share common molecular features. This review presents the available evidence on the properties of α-synuclein oligomers and the potential molecular mechanisms of their cellular disruption. Toxic α-synuclein oligomers may impact cells in a number of ways, including the disruption of membranes, mitochondrial depolarization, cytoskeleton changes, impairment of protein clearance pathways, and enhanced oxidative stress. We also examine the relationship between α-synuclein toxic oligomers and amyloid fibrils, in the light of recent studies that paint a more complex picture of α-synuclein toxicity. Finally, methods of studying and manipulating oligomers within cells are described. |
format | Online Article Text |
id | pubmed-4496673 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-44966732015-07-10 Seeking a Mechanism for the Toxicity of Oligomeric α-Synuclein Roberts, Hazel L. Brown, David R. Biomolecules Review In a number of neurological diseases including Parkinson’s disease (PD), α‑synuclein is aberrantly folded, forming abnormal oligomers, and amyloid fibrils within nerve cells. Strong evidence exists for the toxicity of increased production and aggregation of α-synuclein in vivo. The toxicity of α-synuclein is popularly attributed to the formation of “toxic oligomers”: a heterogenous and poorly characterized group of conformers that may share common molecular features. This review presents the available evidence on the properties of α-synuclein oligomers and the potential molecular mechanisms of their cellular disruption. Toxic α-synuclein oligomers may impact cells in a number of ways, including the disruption of membranes, mitochondrial depolarization, cytoskeleton changes, impairment of protein clearance pathways, and enhanced oxidative stress. We also examine the relationship between α-synuclein toxic oligomers and amyloid fibrils, in the light of recent studies that paint a more complex picture of α-synuclein toxicity. Finally, methods of studying and manipulating oligomers within cells are described. MDPI 2015-03-25 /pmc/articles/PMC4496673/ /pubmed/25816357 http://dx.doi.org/10.3390/biom5020282 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Roberts, Hazel L. Brown, David R. Seeking a Mechanism for the Toxicity of Oligomeric α-Synuclein |
title | Seeking a Mechanism for the Toxicity of Oligomeric α-Synuclein |
title_full | Seeking a Mechanism for the Toxicity of Oligomeric α-Synuclein |
title_fullStr | Seeking a Mechanism for the Toxicity of Oligomeric α-Synuclein |
title_full_unstemmed | Seeking a Mechanism for the Toxicity of Oligomeric α-Synuclein |
title_short | Seeking a Mechanism for the Toxicity of Oligomeric α-Synuclein |
title_sort | seeking a mechanism for the toxicity of oligomeric α-synuclein |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4496673/ https://www.ncbi.nlm.nih.gov/pubmed/25816357 http://dx.doi.org/10.3390/biom5020282 |
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